| Literature DB >> 16623542 |
In Chul Kim1, Andrew D Hamilton.
Abstract
[structure: see text] The design of a nonpeptidic scaffold based on 4,7-diphenyl-1,6-disubstituted indanes mimicking i, i+3, i+4, and i+7 residues of an alpha-helix has been described, and its synthesis has been accomplished. This strategy makes general approaches possible to helix mimetic scaffolds that could be targeted to different proteins by changing the nature of the substituents.Entities:
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Year: 2006 PMID： 16623542 DOI： 10.1021/ol052956q
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005