Literature DB >> 16622252

The iron efflux protein ferroportin regulates the intracellular growth of Salmonella enterica.

Sabine Chlosta1, Douglas S Fishman, Lynne Harrington, Erin E Johnson, Mitchell D Knutson, Marianne Wessling-Resnick, Bobby J Cherayil.   

Abstract

We investigated the influence of the macrophage iron exporter ferroportin and its ligand hepcidin on intracellular Salmonella growth. Elevated ferroportin expression inhibited bacterial multiplication; hepcidin-induced ferroportin down-regulation enhanced it. Expression analysis of iron-responsive Salmonella genes indicated ferroportin-mediated iron deprivation. These results demonstrate a role for ferroportin in antimicrobial resistance.

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Year:  2006        PMID： 16622252      PMCID： PMC1459754          DOI： 10.1128/IAI.74.5.3065-3067.2006

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  28 in total

1.  Presence of the iron exporter ferroportin at the plasma membrane of macrophages is enhanced by iron loading and down-regulated by hepcidin.

Authors:  Constance Delaby; Nathalie Pilard; Ana Sofia Gonçalves; Carole Beaumont; François Canonne-Hergaux
Journal:  Blood       Date:  2005-08-04       Impact factor: 22.113

2.  A novel mammalian iron-regulated protein involved in intracellular iron metabolism.

Authors:  S Abboud; D J Haile
Journal:  J Biol Chem       Date:  2000-06-30       Impact factor: 5.157

3.  Comparative studies of duodenal and macrophage ferroportin proteins.

Authors:  François Canonne-Hergaux; Adriana Donovan; Constance Delaby; Hui-jun Wang; Philippe Gros
Journal:  Am J Physiol Gastrointest Liver Physiol       Date:  2005-08-04       Impact factor: 4.052

4.  The molecular basis of ferroportin-linked hemochromatosis.

Authors:  Ivana De Domenico; Diane McVey Ward; Elizabeta Nemeth; Michael B Vaughn; Giovanni Musci; Tomas Ganz; Jerry Kaplan
Journal:  Proc Natl Acad Sci U S A       Date:  2005-06-13       Impact factor: 11.205

Review 5.  Infections in E-beta thalassemia.

Authors:  W Wanachiwanawin
Journal:  J Pediatr Hematol Oncol       Date:  2000 Nov-Dec       Impact factor: 1.289

6.  Functional consequences of ferroportin 1 mutations.

Authors:  Xiao-Bing Liu; Funmei Yang; David J Haile
Journal:  Blood Cells Mol Dis       Date:  2005 Jul-Aug       Impact factor: 3.039

7.  Association of pulmonary tuberculosis with increased dietary iron.

Authors:  I T Gangaidzo; V M Moyo; E Mvundura; G Aggrey; N L Murphree; H Khumalo; T Saungweme; I Kasvosve; Z A Gomo; T Rouault; J R Boelaert; V R Gordeuk
Journal:  J Infect Dis       Date:  2001-08-17       Impact factor: 5.226

Review 8.  Divalent-metal transport by NRAMP proteins at the interface of host-pathogen interactions.

Authors:  J R Forbes; P Gros
Journal:  Trends Microbiol       Date:  2001-08       Impact factor: 17.079

9.  A mouse model of juvenile hemochromatosis.

Authors:  Franklin W Huang; Jack L Pinkus; Geraldine S Pinkus; Mark D Fleming; Nancy C Andrews
Journal:  J Clin Invest       Date:  2005-08       Impact factor: 14.808

10.  Expression of the duodenal iron transporters divalent-metal transporter 1 and ferroportin 1 in iron deficiency and iron overload.

Authors:  H Zoller; R O Koch; I Theurl; P Obrist; A Pietrangelo; G Montosi; D J Haile; W Vogel; G Weiss
Journal:  Gastroenterology       Date:  2001-05       Impact factor: 22.682
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  72 in total

Review 1.  Iron homeostasis and the inflammatory response.

Authors:  Marianne Wessling-Resnick
Journal:  Annu Rev Nutr       Date:  2010-08-21       Impact factor: 11.848

Review 2.  Are reactive oxygen species always detrimental to pathogens?

Authors:  Claudia N Paiva; Marcelo T Bozza
Journal:  Antioxid Redox Signal       Date:  2013-10-26       Impact factor: 8.401

Review 3.  Iron and immunity: immunological consequences of iron deficiency and overload.

Authors:  Bobby J Cherayil
Journal:  Arch Immunol Ther Exp (Warsz)       Date:  2010-09-28       Impact factor: 4.291

4.  Intestinal innate immunity and the pathogenesis of Salmonella enteritis.

Authors:  Chittur V Srikanth; Bobby J Cherayil
Journal:  Immunol Res       Date:  2007       Impact factor: 2.829

5.  Inverse agonist of estrogen-related receptor γ controls Salmonella typhimurium infection by modulating host iron homeostasis.

Authors:  Don-Kyu Kim; Jae-Ho Jeong; Ji-Min Lee; Kwang Soo Kim; Seung-Hwan Park; Yong Deuk Kim; Minseob Koh; Minsang Shin; Yoon Seok Jung; Hyung-Seok Kim; Tae-Hoon Lee; Byung-Chul Oh; Jae Il Kim; Hwan Tae Park; Won-Il Jeong; Chul-Ho Lee; Seung Bum Park; Jung-Joon Min; Sook-In Jung; Seok-Yong Choi; Hyon E Choy; Hueng-Sik Choi
Journal:  Nat Med       Date:  2014-03-23       Impact factor: 53.440

Review 6.  Bacterial manipulation of innate immunity to promote infection.

Authors:  Lautaro Diacovich; Jean-Pierre Gorvel
Journal:  Nat Rev Microbiol       Date:  2010-02       Impact factor: 60.633

7.  Iron and inflammation: cross-talk between pathways regulating hepcidin.

Authors:  Robert E Fleming
Journal:  J Mol Med (Berl)       Date:  2008-05       Impact factor: 4.599

8.  Modulation of iron homeostasis in macrophages by bacterial intracellular pathogens.

Authors:  Xin Pan; Batcha Tamilselvam; Eric J Hansen; Simon Daefler
Journal:  BMC Microbiol       Date:  2010-02-25       Impact factor: 3.605

Review 9.  Iron in innate immunity: starve the invaders.

Authors:  Tomas Ganz
Journal:  Curr Opin Immunol       Date:  2009-02-21       Impact factor: 7.486

10.  Time-course analysis of serum hepcidin, iron and cytokines in a C282Y homozygous patient with Schnitzler's syndrome treated with IL-1 receptor antagonist.

Authors:  Marcel van Deuren; Joyce J C Kroot; Dorine W Swinkels
Journal:  Haematologica       Date:  2009-07-16       Impact factor: 9.941
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