Literature DB >> 16622241

The posttranscriptional regulator RsmA plays a role in the interaction between Pseudomonas aeruginosa and human airway epithelial cells by positively regulating the type III secretion system.

Heidi Mulcahy1, Julie O'Callaghan, Eoin P O'Grady, Claire Adams, Fergal O'Gara.   

Abstract

Posttranscriptional regulation of certain virulence-related genes in Pseudomonas aeruginosa is brought about by RsmA, a small RNA-binding protein. During interaction with airway epithelial cells, RsmA promoted actin depolymerization, cytotoxicity, and anti-internalization of P. aeruginosa by positively regulating the virulence-associated type III secretion system.

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Year:  2006        PMID： 16622241      PMCID： PMC1459696          DOI： 10.1128/IAI.74.5.3012-3015.2006

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  32 in total

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2.  Coordinate regulation of bacterial virulence genes by a novel adenylate cyclase-dependent signaling pathway.

Authors:  Matthew C Wolfgang; Vincent T Lee; Meghan E Gilmore; Stephen Lory
Journal:  Dev Cell       Date:  2003-02       Impact factor: 12.270

3.  A novel anti-anti-activator mechanism regulates expression of the Pseudomonas aeruginosa type III secretion system.

Authors:  Nandini Dasgupta; Guinevere L Lykken; Matthew C Wolfgang; Timothy L Yahr
Journal:  Mol Microbiol       Date:  2004-07       Impact factor: 3.501

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Journal:  J Bacteriol       Date:  1997-03       Impact factor: 3.490

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Journal:  Infect Immun       Date:  1996-10       Impact factor: 3.441

6.  Analyses of the DNA-binding and transcriptional activation properties of ExsA, the transcriptional activator of the Pseudomonas aeruginosa exoenzyme S regulon.

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Journal:  J Bacteriol       Date:  1995-08       Impact factor: 3.490

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Authors:  D W Frank
Journal:  Mol Microbiol       Date:  1997-11       Impact factor: 3.501

8.  Defects in type III secretion correlate with internalization of Pseudomonas aeruginosa by epithelial cells.

Authors:  A R Hauser; S Fleiszig; P J Kang; K Mostov; J N Engel
Journal:  Infect Immun       Date:  1998-04       Impact factor: 3.441

9.  Expression stability of six housekeeping genes: A proposal for resistance gene quantification studies of Pseudomonas aeruginosa by real-time quantitative RT-PCR.

Authors:  Hakan Savli; Aynur Karadenizli; Fetiye Kolayli; Sibel Gundes; Ugur Ozbek; Haluk Vahaboglu
Journal:  J Med Microbiol       Date:  2003-05       Impact factor: 2.472

10.  Positive control of swarming, rhamnolipid synthesis, and lipase production by the posttranscriptional RsmA/RsmZ system in Pseudomonas aeruginosa PAO1.

Authors:  Karin Heurlier; Faye Williams; Stephan Heeb; Corinne Dormond; Gabriella Pessi; Dustin Singer; Miguel Cámara; Paul Williams; Dieter Haas
Journal:  J Bacteriol       Date:  2004-05       Impact factor: 3.490
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  37 in total

1.  Derivatives of plant phenolic compound affect the type III secretion system of Pseudomonas aeruginosa via a GacS-GacA two-component signal transduction system.

Authors:  Akihiro Yamazaki; Jin Li; Quan Zeng; Devanshi Khokhani; William C Hutchins; Angela C Yost; Eulandria Biddle; Eric J Toone; Xin Chen; Ching-Hong Yang
Journal:  Antimicrob Agents Chemother       Date:  2011-10-03       Impact factor: 5.191

Review 2.  Post-transcriptional global regulation by CsrA in bacteria.

Authors:  Johan Timmermans; Laurence Van Melderen
Journal:  Cell Mol Life Sci       Date:  2010-05-06       Impact factor: 9.261

3.  Determination of the regulon and identification of novel mRNA targets of Pseudomonas aeruginosa RsmA.

Authors:  Anja Brencic; Stephen Lory
Journal:  Mol Microbiol       Date:  2009-05       Impact factor: 3.501

Review 4.  Regulation of bacterial virulence by Csr (Rsm) systems.

Authors:  Christopher A Vakulskas; Anastasia H Potts; Paul Babitzke; Brian M M Ahmer; Tony Romeo
Journal:  Microbiol Mol Biol Rev       Date:  2015-06       Impact factor: 11.056

5.  Effects of 14-alpha-lipoyl andrographolide on quorum sensing in Pseudomonas aeruginosa.

Authors:  Li Ma; Xiangyang Liu; Haihua Liang; Yizhou Che; Caixia Chen; Huanqin Dai; Ke Yu; Mei Liu; Luyan Ma; Ching-Hong Yang; Fuhang Song; Yuqiang Wang; Lixin Zhang
Journal:  Antimicrob Agents Chemother       Date:  2012-07-16       Impact factor: 5.191

6.  RNase E Promotes Expression of Type III Secretion System Genes in Pseudomonas aeruginosa.

Authors:  Josh S Sharp; Arne Rietsch; Simon L Dove
Journal:  J Bacteriol       Date:  2019-10-21       Impact factor: 3.490

7.  Functional Analyses of the RsmY and RsmZ Small Noncoding Regulatory RNAs in Pseudomonas aeruginosa.

Authors:  Kayley H Janssen; Manisha R Diaz; Matthew Golden; Justin W Graham; Wes Sanders; Matthew C Wolfgang; Timothy L Yahr
Journal:  J Bacteriol       Date:  2018-05-09       Impact factor: 3.490

8.  Pseudomonas aeruginosa RsmA plays an important role during murine infection by influencing colonization, virulence, persistence, and pulmonary inflammation.

Authors:  Heidi Mulcahy; Julie O'Callaghan; Eoin P O'Grady; María D Maciá; Nuria Borrell; Cristina Gómez; Pat G Casey; Colin Hill; Claire Adams; Cormac G M Gahan; Antonio Oliver; Fergal O'Gara
Journal:  Infect Immun       Date:  2007-11-19       Impact factor: 3.441

9.  Pseudomonas aeruginosa AlgU Contributes to Posttranscriptional Activity by Increasing rsmA Expression in a mucA22 Strain.

Authors:  Sean D Stacey; Christopher L Pritchett
Journal:  J Bacteriol       Date:  2016-06-13       Impact factor: 3.490

10.  Small RNA-dependent expression of secondary metabolism is controlled by Krebs cycle function in Pseudomonas fluorescens.

Authors:  Kasumi Takeuchi; Patrick Kiefer; Cornelia Reimmann; Christoph Keel; Christophe Dubuis; Joëlle Rolli; Julia A Vorholt; Dieter Haas
Journal:  J Biol Chem       Date:  2009-10-19       Impact factor: 5.157
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