Literature DB >> 1662204

IgE-induced tyrosine phosphorylation of phospholipase C-gamma 1 in rat basophilic leukemia cells.

D J Park1, H K Min, S G Rhee.   

Abstract

Stimulation of rat basophilic leukemia (RBL-2H3) cells with oligomeric IgE elicited a rapid and transient phosphorylation of phospholipase C (PLC)-gamma 1 on tyrosine residues. Prior incubation of RBL-2H3 cells with a protein tyrosine kinase inhibitor, herbimycin A, prevented the tyrosine phosphorylation of PLC-gamma 1 as well as the hydrolysis of phosphatidylinositol 4,5-bisphosphate induced by oligomeric IgE. However, 5'-(N-ethyl)carboxamidoadenosine, which is known to activate PLC through a G protein, did not elicit tyrosine phosphorylation of PLC-gamma 1. These results, together with previous findings showing that tyrosine phosphorylation of PLC-gamma 1 enhances its catalytic activity, indicate that phosphorylation of PLC-gamma 1 by a nonreceptor tyrosine kinase is the mechanism by which IgE receptor aggregation triggers PLC activation.

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Year:  1991        PMID： 1662204

Source DB:  PubMed          Journal:  J Biol Chem        ISSN： 0021-9258            Impact factor:   5.157


  45 in total

1.  Vav1 regulates phospholipase cgamma activation and calcium responses in mast cells.

Authors:  T S Manetz; C Gonzalez-Espinosa; R Arudchandran; S Xirasagar; V Tybulewicz; J Rivera
Journal:  Mol Cell Biol       Date:  2001-06       Impact factor: 4.272

Review 2.  Inositol-lipid-specific phospholipase C isoenzymes and their differential regulation by receptors.

Authors:  S Cockcroft; G M Thomas
Journal:  Biochem J       Date:  1992-11-15       Impact factor: 3.857

3.  The SH2 and SH3 domain-containing Nck protein is oncogenic and a common target for phosphorylation by different surface receptors.

Authors:  W Li; P Hu; E Y Skolnik; A Ullrich; J Schlessinger
Journal:  Mol Cell Biol       Date:  1992-12       Impact factor: 4.272

4.  Fc epsilon RI-mediated tyrosine phosphorylation and activation of the 72-kDa protein-tyrosine kinase, PTK72, in RBL-2H3 rat tumor mast cells.

Authors:  J E Hutchcroft; R L Geahlen; G G Deanin; J M Oliver
Journal:  Proc Natl Acad Sci U S A       Date:  1992-10-01       Impact factor: 11.205

5.  Phosphorylation/dephosphorylation of high-affinity IgE receptors: a mechanism for coupling/uncoupling a large signaling complex.

Authors:  R Paolini; R Numerof; J P Kinet
Journal:  Proc Natl Acad Sci U S A       Date:  1992-11-15       Impact factor: 11.205

6.  The yeast and mammalian isoforms of phosphatidylinositol transfer protein can all restore phospholipase C-mediated inositol lipid signaling in cytosol-depleted RBL-2H3 and HL-60 cells.

Authors:  E Cunningham; S K Tan; P Swigart; J Hsuan; V Bankaitis; S Cockcroft
Journal:  Proc Natl Acad Sci U S A       Date:  1996-06-25       Impact factor: 11.205

7.  A protein that is highly related to GTPase-activating protein-associated p62 complexes with phospholipase C gamma.

Authors:  M C Maa; T H Leu; B J Trandel; J H Chang; S J Parsons
Journal:  Mol Cell Biol       Date:  1994-08       Impact factor: 4.272

8.  Conversion of epidermal growth factor (EGF) into a stimulatory ligand for A431-cell growth by herbimycin A by decreasing the level of expression of EGF receptor.

Authors:  Y Murakami; H Fukazawa; S Mizuno; Y Uehara
Journal:  Biochem J       Date:  1994-07-01       Impact factor: 3.857

9.  Source of nuclear calcium signals.

Authors:  N L Allbritton; E Oancea; M A Kuhn; T Meyer
Journal:  Proc Natl Acad Sci U S A       Date:  1994-12-20       Impact factor: 11.205

10.  Thy-1 glycoprotein and src-like protein-tyrosine kinase p53/p56lyn are associated in large detergent-resistant complexes in rat basophilic leukemia cells.

Authors:  L Dráberová; P Dráber
Journal:  Proc Natl Acad Sci U S A       Date:  1993-04-15       Impact factor: 11.205
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