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Literature DB >> 16621839

Induction of Escherichia coli chromosomal mazEF by stressful conditions causes an irreversible loss of viability.

Ilana Kolodkin-Gal¹, Hanna Engelberg-Kulka.

Abstract

mazEF is a stress-induced toxin-antitoxin module located on the chromosomes of many bacteria. Here we induced Escherichia coli chromosomal mazEF by various stressful conditions. We found an irreversible loss of viability, which is the basic characteristic of cell death. These results further support our previous conclusion that E. coli mazEF mediation of cell death is not a passive process, but an active and genetically "programmed" death response.

Entities: Gene Species

Mesh：

Substances：

Year: 2006 PMID： 16621839 PMCID： PMC1447462 DOI： 10.1128/JB.188.9.3420-3423.2006

Source DB: PubMed Journal: J Bacteriol ISSN： 0021-9193 Impact factor: 3.490

35 in total

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6. Programmed cell death in Escherichia coli: some antibiotics can trigger mazEF lethality.

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Journal: J Mol Microbiol Biotechnol Date: 1999-11

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46 in total

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