OBJECTIVE: The description and evaluation of the performance of a new real-time seizure detection algorithm in the newborn infant. METHODS: The algorithm includes parallel fragmentation of EEG signal into waves; wave-feature extraction and averaging; elementary, preliminary and final detection. The algorithm detects EEG waves with heightened regularity, using wave intervals, amplitudes and shapes. The performance of the algorithm was assessed with the use of event-based and liberal and conservative time-based approaches and compared with the performance of Gotman's and Liu's algorithms. RESULTS: The algorithm was assessed on multi-channel EEG records of 55 neonates including 17 with seizures. The algorithm showed sensitivities ranging 83-95% with positive predictive values (PPV) 48-77%. There were 2.0 false positive detections per hour. In comparison, Gotman's algorithm (with 30s gap-closing procedure) displayed sensitivities of 45-88% and PPV 29-56%; with 7.4 false positives per hour and Liu's algorithm displayed sensitivities of 96-99%, and PPV 10-25%; with 15.7 false positives per hour. CONCLUSIONS: The wave-sequence analysis based algorithm displayed higher sensitivity, higher PPV and a substantially lower level of false positives than two previously published algorithms. SIGNIFICANCE: The proposed algorithm provides a basis for major improvements in neonatal seizure detection and monitoring.
OBJECTIVE: The description and evaluation of the performance of a new real-time seizure detection algorithm in the newborn infant. METHODS: The algorithm includes parallel fragmentation of EEG signal into waves; wave-feature extraction and averaging; elementary, preliminary and final detection. The algorithm detects EEG waves with heightened regularity, using wave intervals, amplitudes and shapes. The performance of the algorithm was assessed with the use of event-based and liberal and conservative time-based approaches and compared with the performance of Gotman's and Liu's algorithms. RESULTS: The algorithm was assessed on multi-channel EEG records of 55 neonates including 17 with seizures. The algorithm showed sensitivities ranging 83-95% with positive predictive values (PPV) 48-77%. There were 2.0 false positive detections per hour. In comparison, Gotman's algorithm (with 30s gap-closing procedure) displayed sensitivities of 45-88% and PPV 29-56%; with 7.4 false positives per hour and Liu's algorithm displayed sensitivities of 96-99%, and PPV 10-25%; with 15.7 false positives per hour. CONCLUSIONS: The wave-sequence analysis based algorithm displayed higher sensitivity, higher PPV and a substantially lower level of false positives than two previously published algorithms. SIGNIFICANCE: The proposed algorithm provides a basis for major improvements in neonatal seizure detection and monitoring.
Authors: Andriy Temko; Gordon Lightbody; Eoin M Thomas; Geraldine B Boylan; William Marnane Journal: IEEE Trans Biomed Eng Date: 2011-12-07 Impact factor: 4.538
Authors: Joyeeta Mitra; John R Glover; Periklis Y Ktonas; Arun Thitai Kumar; Amit Mukherjee; Nicolaos B Karayiannis; James D Frost; Richard A Hrachovy; Eli M Mizrahi Journal: J Clin Neurophysiol Date: 2009-08 Impact factor: 2.177
Authors: Linda G M van Rooij; Marcel P H van den Broek; Carin M A Rademaker; Linda S de Vries Journal: Paediatr Drugs Date: 2013-02 Impact factor: 3.022