| Literature DB >> 16621674 |
Ryoji Yanai1, Naoyuki Yamada, Kiichi Ueda, Motoharu Tajiri, Toru Matsumoto, Keiji Kido, Shigeru Nakamura, Fumio Saito, Teruo Nishida.
Abstract
Povidone-iodine (PVP-I) possesses broad-spectrum antimicrobial activity and is used clinically as a disinfectant. We evaluated the disinfectant properties and safety of PVP-I for use as a contact lens solution. The concentrations of PVP-I required to reduce the number of Staphylococcus aureus or Candida albicans by 3 log units were lower than were those of hydrogen peroxide, polyhexamethylene biguanide (PHMB), and benzalkonium chloride (BAK). The cytotoxicity of PVP-I for cultured human corneal epithelial (HCE) cells was less than that of the other three agents. The safety margin for PVP-I was thus greatest among the tested compounds. PVP-I appears suited for use as a contact lens disinfectant.Entities:
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Year: 2006 PMID： 16621674 DOI： 10.1016/j.clae.2006.02.006
Source DB: PubMed Journal: Cont Lens Anterior Eye ISSN： 1367-0484 Impact factor: 3.077