BACKGROUND: Although excessive daytime sleepiness (EDS) in Parkinson's disease (PD) has received a great deal of attention, the underlying pathological mechanism of its development and the relative contributions of brain function to this process are poorly understood. OBJECTIVE: To compare the fractional anisotropy (FA) values of PD patients with EDS and those without EDS, and to investigate the mechanism of EDS in this disease. METHODS: Eleven patients with PD with EDS, 26 patients with PD without EDS and 10 controls participated in this study. Patients with an ESS (Epworth Sleepiness Scale) score >or=10 were defined as having EDS. The FA values of 5 regions of interest (ROI) including the fornix were compared between the three groups. RESULTS: There were significant reductions in FA values of the fornix fiber in patients with EDS. ESS scores had significant correlation with FA values of the fornix. CONCLUSIONS: Our study is the first to find the fornix fiber degeneration in PD patients with EDS. These results indicate that fornix dysfunction may have some correlations with EDS in PD.
BACKGROUND: Although excessive daytime sleepiness (EDS) in Parkinson's disease (PD) has received a great deal of attention, the underlying pathological mechanism of its development and the relative contributions of brain function to this process are poorly understood. OBJECTIVE: To compare the fractional anisotropy (FA) values of PDpatients with EDS and those without EDS, and to investigate the mechanism of EDS in this disease. METHODS: Eleven patients with PD with EDS, 26 patients with PD without EDS and 10 controls participated in this study. Patients with an ESS (Epworth Sleepiness Scale) score >or=10 were defined as having EDS. The FA values of 5 regions of interest (ROI) including the fornix were compared between the three groups. RESULTS: There were significant reductions in FA values of the fornix fiber in patients with EDS. ESS scores had significant correlation with FA values of the fornix. CONCLUSIONS: Our study is the first to find the fornix fiber degeneration in PDpatients with EDS. These results indicate that fornix dysfunction may have some correlations with EDS in PD.
Authors: Marcus M Unger; Marcus Belke; Katja Menzler; Johannes T Heverhagen; Boris Keil; Karin Stiasny-Kolster; Felix Rosenow; Nico J Diederich; Geert Mayer; Jens C Möller; Wolfgang H Oertel; Susanne Knake Journal: Sleep Date: 2010-06 Impact factor: 5.849
Authors: Michael D Boska; Khader M Hasan; Danette Kibuule; Rebecca Banerjee; Erin McIntyre; Jay A Nelson; Theresa Hahn; Howard E Gendelman; R Lee Mosley Journal: Neurobiol Dis Date: 2007-03-06 Impact factor: 5.996