PURPOSE: To evaluate the role of intravenous methyl prednisolone in patients with solitary cysticercus granuloma with new-onset seizures. METHODS: In this open-label, randomized, prospective, follow-up study, 52 patients with new-onset seizures and a single enhancing CT lesion of cysticercus were randomly divided in two groups to receive either intravenous methyl prednisolone for 5 days along with antiepileptic drug (n=25) or antiepileptic drug monotherapy (n=27) alone. The patients were followed up for at least for 9 months. Repeat CT scans were performed after 2 months. RESULTS: After 2 months, lesion disappeared in 60% patients of intravenous methyl prednisolone group and 18.5% patients receiving only antiepileptic drug (p=0.001). As far as seizure recurrence was concerned, a lower number (16% versus 33%) of intravenous methyl prednisolone treated patient had recurrence, the difference was insignificant. CONCLUSION:Intravenous methyl prednisolone therapy helps in early resolution of solitary cysticercus granuloma.
RCT Entities:
PURPOSE: To evaluate the role of intravenous methyl prednisolone in patients with solitary cysticercus granuloma with new-onset seizures. METHODS: In this open-label, randomized, prospective, follow-up study, 52 patients with new-onset seizures and a single enhancing CT lesion of cysticercus were randomly divided in two groups to receive either intravenous methyl prednisolone for 5 days along with antiepileptic drug (n=25) or antiepileptic drug monotherapy (n=27) alone. The patients were followed up for at least for 9 months. Repeat CT scans were performed after 2 months. RESULTS: After 2 months, lesion disappeared in 60% patients of intravenous methyl prednisolone group and 18.5% patients receiving only antiepileptic drug (p=0.001). As far as seizure recurrence was concerned, a lower number (16% versus 33%) of intravenous methyl prednisolone treated patient had recurrence, the difference was insignificant. CONCLUSION: Intravenous methyl prednisolone therapy helps in early resolution of solitary cysticercus granuloma.
Authors: Hector H Garcia; Isidro Gonzales; Andres G Lescano; Javier A Bustos; E Javier Pretell; Herbert Saavedra; Theodore E Nash Journal: Epilepsia Date: 2014-08-04 Impact factor: 5.864
Authors: Javier A Bustos; Gianfranco Arroyo; Robert H Gilman; Percy Soto-Becerra; Isidro Gonzales; Herbert Saavedra; E Javier Pretell; Theodore E Nash; Seth E O'Neal; Oscar H Del Brutto; Armando E Gonzalez; Hector H Garcia Journal: Clin Infect Dis Date: 2021-11-02 Impact factor: 20.999
Authors: Annette Abraham; Javier A Bustos; Hélène Carabin; Robert de Meijere; Priyadarshi S Sahu; Vedantam Rajshekhar; Gagandeep Singh; A Clinton White; Peter L Chiodini; Sarah Gabriël; Mamoun Homeida; Theodore Nash; Bernard Ngowi; Xiao Nong Zhou; Christina Coyle; Hector H Garcia; Andrea S Winkler Journal: PLoS Negl Trop Dis Date: 2021-03-31