| Literature DB >> 16621542 |
Ulrich Abel1, Werner Simon, Peter Eckard, Friedrich G Hansske.
Abstract
We report the design, semisynthesis, and biological activity of a series of fredericamycin (1) derivatives. Within this series compound 1e combines low nanomolar cytotoxic potency in vitro, increased tumor cell line selectivity, and in vivo activity in a human xenograft model.Entities:
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Year: 2006 PMID： 16621542 DOI： 10.1016/j.bmcl.2006.03.029
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823