| Literature DB >> 16620919 |
Michihiko Fujii1, Yoshinori Kawai, Morio Endoh, Mohammad Nazir Hossain, Kazuhiko Nakabayashi, Dai Ayusawa.
Abstract
Immortal SVts8 cells that express thermolabile SV40 T antigen exhibit a senescence-like phenomenon upon inactivation of the T antigen. By using a cDNA subtractive hybridization technique, RAB27B, a member of the RAB GTPase family, was found to be up-regulated in senescent SVts8 cells. The up-regulation of RAB27B depends on the p53 gene. Enhanced expression was also observed in replicative senescence in normal human fibroblasts.Entities:
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Year: 2006 PMID： 16620919 DOI： 10.1016/j.mad.2006.03.001
Source DB: PubMed Journal: Mech Ageing Dev ISSN： 0047-6374 Impact factor: 5.432