BACKGROUND: Whereas several epidemiological studies suggest that low dietary intake of vitamins C and E is linked to increased hip fracture in smokers and antioxidants (dietary and endogenous) are reduced in elderly osteoporotic women, none has demonstrated an effect of supplemental antioxidants on bone turnover. METHODS: In an observational study of 533 randomly selected women, we investigated the associations among the use of antioxidant supplements, vitamins C and E, serum levels of biochemical markers of bone turnover (C-telopeptide [CTx] and bone-specific alkaline phosphatase [BSAP]), and whole body bone mineral density (BMD). RESULTS: Twenty-two women were identified as current users of supplemental vitamin C or E. Duration of antioxidant supplement use was negatively associated with age-adjusted and weight-adjusted serum CTx, such that mean CTx levels (natural log transformed) were 0.022 units lower for each year of exposure. No significant differences were detected for adjusted serum BSAP or whole body BMD. CONCLUSIONS: Our results suggest that antioxidant vitamin E or C supplements may suppress bone resorption in nonsmoking postmenopausal women. Coupling of bone formation and resorption may explain the absence of an effect on bone formation markers, given evidence of enhanced effects of antioxidants on osteoblast differentiation; this warrants further investigation. This work adds to the growing body of evidence that antioxidants may play a role in preventing osteoporosis.
BACKGROUND: Whereas several epidemiological studies suggest that low dietary intake of vitamins C and E is linked to increased hip fracture in smokers and antioxidants (dietary and endogenous) are reduced in elderly osteoporoticwomen, none has demonstrated an effect of supplemental antioxidants on bone turnover. METHODS: In an observational study of 533 randomly selected women, we investigated the associations among the use of antioxidant supplements, vitamins C and E, serum levels of biochemical markers of bone turnover (C-telopeptide [CTx] and bone-specific alkaline phosphatase [BSAP]), and whole body bone mineral density (BMD). RESULTS: Twenty-two women were identified as current users of supplemental vitamin C or E. Duration of antioxidant supplement use was negatively associated with age-adjusted and weight-adjusted serum CTx, such that mean CTx levels (natural log transformed) were 0.022 units lower for each year of exposure. No significant differences were detected for adjusted serum BSAP or whole body BMD. CONCLUSIONS: Our results suggest that antioxidant vitamin E or C supplements may suppress bone resorption in nonsmoking postmenopausal women. Coupling of bone formation and resorption may explain the absence of an effect on bone formation markers, given evidence of enhanced effects of antioxidants on osteoblast differentiation; this warrants further investigation. This work adds to the growing body of evidence that antioxidants may play a role in preventing osteoporosis.
Authors: A Chuin; M Labonté; D Tessier; A Khalil; F Bobeuf; C Y Doyon; N Rieth; I J Dionne Journal: Osteoporos Int Date: 2008-11-20 Impact factor: 4.507
Authors: K Holvik; C G Gjesdal; G S Tell; G Grimnes; B Schei; E M Apalset; S O Samuelsen; R Blomhoff; K Michaëlsson; H E Meyer Journal: Osteoporos Int Date: 2014-07-26 Impact factor: 4.507
Authors: Shivani Sahni; Marian T Hannan; David Gagnon; Jeffrey Blumberg; L Adrienne Cupples; Douglas P Kiel; Katherine L Tucker Journal: J Nutr Date: 2008-10 Impact factor: 4.798
Authors: Shivani Sahni; Marian T Hannan; Jeffrey Blumberg; L Adrienne Cupples; Douglas P Kiel; Katherine L Tucker Journal: Am J Clin Nutr Date: 2008-12-03 Impact factor: 7.045