| Literature DB >> 16620104 |
Rosalba Cannella1, Angelo Clerici, Walter Panzeri, Nadia Pastori, Carlo Punta, Ombretta Porta.
Abstract
A new reaction of general synthetic interest representing the free-radical version of the Strecker synthesis to alpha-aminoamides is reported. A hydroxy radical, generated by Ti(III) one-electron reduction of H2O2, abstracts a H atom from the C-H bond of formamide, and the resulting carbamoyl radical adds to the C atom of aldimines formed in situ, leading to a one-pot synthesis of alpha-aminoamides. Several types of aldehydes can participate in this process.Entities:
Year: 2006 PMID： 16620104 DOI： 10.1021/ja061092g
Source DB: PubMed Journal: J Am Chem Soc ISSN： 0002-7863 Impact factor: 15.419