BACKGROUND: The applicability of the melanoma antigen gene (MAGE) to the molecular diagnosis of cancer, by detecting MAGE mRNA in the sputa of head and neck cancer patients, was investigated. MATERIALS AND METHODS: Nested reverse transcription-polymerase chain reaction (RT-PCR) with the MAGE common primers designed to detect MAGE A1-6 genes was conducted with sputa of 17 head and neck squamous cell carcinoma patients. RESULTS: Of the 17 sputa specimens from patients with squamous cell carcinoma, MAGE mRNA was detected in 13 cases, while the detection rate was 2 out of 40 in the normal control group, showing significant correlation (p<0.05) between head and neck squamous cell carcinoma and MAGE mRNA expression in sputa. CONCLUSION: MAGE may be a useful tumor marker of head and neck cancer.
BACKGROUND: The applicability of the melanoma antigen gene (MAGE) to the molecular diagnosis of cancer, by detecting MAGE mRNA in the sputa of head and neck cancerpatients, was investigated. MATERIALS AND METHODS: Nested reverse transcription-polymerase chain reaction (RT-PCR) with the MAGE common primers designed to detect MAGE A1-6 genes was conducted with sputa of 17 head and neck squamous cell carcinomapatients. RESULTS: Of the 17 sputa specimens from patients with squamous cell carcinoma, MAGE mRNA was detected in 13 cases, while the detection rate was 2 out of 40 in the normal control group, showing significant correlation (p<0.05) between head and neck squamous cell carcinoma and MAGE mRNA expression in sputa. CONCLUSION: MAGE may be a useful tumor marker of head and neck cancer.
Authors: Urs D A Müller-Richter; Albert Dowejko; Oliver Driemel; Tobias Reuther; Torsten E Reichert; Alexander C Kübler Journal: Oncol Lett Date: 2010-01-01 Impact factor: 2.967
Authors: Urs D A Müller-Richter; Albert Dowejko; Silvia Peters; Stephan Rauthe; Tobias Reuther; Stefan Gattenlöhner; Torsten E Reichert; Oliver Driemel; Alexander C Kübler Journal: Clin Oral Investig Date: 2009-06-02 Impact factor: 3.573