OBJECTIVE: To investigate PLAC1/CP1 as a potential candidate gene in gastric cancer therapy. METHODS: Reverse transcription-polymerase chain reaction (RT-PCR) method was used to detect the expression of PLAC1/CP1 mRNA in gastric cancer tissues and paired adjacent non-cancerous tissues resected from 28 patients with gastric cancer. Specific antibodies against PLAC1/CP1 were also detected by ELISA method in gastric cancer patients. RESULTS: Fourteen (50%,14/28) out of the 28 gastric cancer samples were PLAC1/CP1 mRNA positive. Of the 28 serum samples tested,eight (29%,8/28) displayed positive seroreactivity against PLAC1/CP1 antigen, accounting for 57% (8/14) of PLAC1/CP1 mRNA positive samples. CONCLUSION: PLAC1/CP1 mRNA was expressed in high frequency and induced spontaneous antibody responses in gastric cancer patients. PLAC1/CP1 may be a valuable candidate antigen in gastric cancer immunotherapy.
OBJECTIVE: To investigate PLAC1/CP1 as a potential candidate gene in gastric cancer therapy. METHODS: Reverse transcription-polymerase chain reaction (RT-PCR) method was used to detect the expression of PLAC1/CP1 mRNA in gastric cancer tissues and paired adjacent non-cancerous tissues resected from 28 patients with gastric cancer. Specific antibodies against PLAC1/CP1 were also detected by ELISA method in gastric cancerpatients. RESULTS: Fourteen (50%,14/28) out of the 28 gastric cancer samples were PLAC1/CP1 mRNA positive. Of the 28 serum samples tested,eight (29%,8/28) displayed positive seroreactivity against PLAC1/CP1 antigen, accounting for 57% (8/14) of PLAC1/CP1 mRNA positive samples. CONCLUSION:PLAC1/CP1 mRNA was expressed in high frequency and induced spontaneous antibody responses in gastric cancerpatients. PLAC1/CP1 may be a valuable candidate antigen in gastric cancer immunotherapy.
Authors: Eric J Devor; Henry D Reyes; Jesus Gonzalez-Bosquet; Akshaya Warrier; Susan A Kenzie; Nonye V Ibik; Marina D Miller; Brandon M Schickling; Michael J Goodheart; Kristina W Thiel; Kimberly K Leslie Journal: Int J Gynecol Cancer Date: 2017-05 Impact factor: 3.437
Authors: Wilson A Silva; Sacha Gnjatic; Erika Ritter; Ramon Chua; Tzeela Cohen; Melinda Hsu; Achim A Jungbluth; Nasser K Altorki; Yao-Tseng Chen; Lloyd J Old; Andrew J G Simpson; Otavia L Caballero Journal: Cancer Immun Date: 2007-11-06
Authors: Eric J Devor; Henry D Reyes; Donna A Santillan; Mark K Santillan; Chinenye Onukwugha; Michael J Goodheart; Kimberly K Leslie Journal: Obstet Gynecol Int Date: 2014-03-17
Authors: Eric J Devor; Jesus Gonzalez-Bosquet; Akshaya Warrier; Henry D Reyes; Nonye V Ibik; Brandon M Schickling; Andreea Newtson; Michael J Goodheart; Kimberly K Leslie Journal: Int J Oncol Date: 2017-03-23 Impact factor: 5.650