| Literature DB >> 16616922 |
Georges Tabarani1, José J Reina, Christine Ebel, Corinne Vivès, Hugues Lortat-Jacob, Javier Rojo, Franck Fieschi.
Abstract
DC-SIGN (dendritic cell-specific ICAM-3 grabbing non-integrin) is a C-type lectin receptor of dendritic cells and is involved in the initial steps of numerous infectious diseases. Surface plasmon resonance has been used to study the affinity of a glycodendritic polymer with 32 mannoses, to DC-SIGN. This glycodendrimer binds to DC-SIGN surfaces in the submicromolar range. This binding depends on a clustered organization of DC-SIGN mimicking its natural organization as microdomain in the dendritic cells plasma membrane. Moreover, this compound inhibits DC-SIGN binding to the HIV glycoprotein gp120 with an IC50 in the micromolar range and therefore can be considered as a potential antiviral drug.Entities:
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Year: 2006 PMID： 16616922 DOI： 10.1016/j.febslet.2006.03.061
Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124