Literature DB >> 16616791

Inhibitory effect of total flavone of Abelmoschus manihot L. Medic on NMDA receptor-mediated current in cultured rat hippocampal neurons.

Xin-Ping Cheng1, Song Qin, Liu-Yi Dong, Jiang-Ning Zhou.   

Abstract

The modulatory effect of Total Flavone of Abelmoschus manihot L. Medic (TFA) on NMDA-activated current (I(NMDA)) was investigated in cultured rat hippocampal neurons using the whole-cell patch-clamp technique. TFA rapidly and reversibly inhibited the I(NMDA) in a concentration-dependent manner. Furthermore, TFA non-competitively inhibited the I(NMDA) by enhancement of the NMDA receptor desensitization. In addition, intracellular application of TFA did not alter the TFA inhibition of I(NMDA). These results suggest that the inhibition of the NMDA receptor response by TFA could be one of the mechanisms for TFA-mediated neuroprotective actions.

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Year:  2006        PMID： 16616791     DOI： 10.1016/j.neures.2006.02.011

Source DB:  PubMed          Journal:  Neurosci Res        ISSN： 0168-0102            Impact factor:   3.304


  4 in total

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  4 in total

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