| Literature DB >> 16616459 |
C M Schramm1, L Guernsey, E Secor, R S Thrall.
Abstract
Ovalbumin (OVA)-sensitized wildtype (WT) and endotoxin-resistant (ER) mice developed similar degrees of airways eosinophilia and serum OVA-specific IgE levels after acute aerosolized OVA challenge. WT mice demonstrated methacholine hyperreactivity, whereas ER mice showed no change in responsiveness. With chronic aerosolized OVA challenge, both WT and ER mice developed local tolerance, with resolution of airway eosinophilia but persistence of anti-OVA IgE in serum. Thus, the development of local tolerance with chronic aerosol exposure to OVA is independent of any potential effects of endotoxin in the OVA aerosol solution.Entities:
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Year: 2006 PMID： 16616459 DOI： 10.1016/j.bbadis.2006.02.002
Source DB: PubMed Journal: Biochim Biophys Acta ISSN： 0006-3002