| Literature DB >> 16616334 |
Lixin Sun1, Ai-Min Hui, Qin Su, Alexander Vortmeyer, Yuri Kotliarov, Sandra Pastorino, Antonino Passaniti, Jayant Menon, Jennifer Walling, Rolando Bailey, Marc Rosenblum, Tom Mikkelsen, Howard A Fine.
Abstract
Stem cell factor (SCF) is overexpressed by neurons following brain injury as well as by glioma cells; however, its role in gliomagenesis remains unclear. Here, we demonstrate that SCF directly activates brain microvascular endothelial cells (ECs) in vitro and induces a potent angiogenic response in vivo. Primary human gliomas express SCF in a grade-dependent manner and induce normal neurons to express SCF in brain regions infiltrated by glioma cells, areas that colocalize with prominent angiogenesis. Downregulation of SCF inhibits tumor-mediated angiogenesis and glioma growth in vivo, whereas overexpression of SCF is associated with shorter survival in patients with malignant gliomas. Thus, the SCF/c-Kit pathway plays an important role in tumor- and normal host cell-induced angiogenesis within the brain.Entities:
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Year: 2006 PMID： 16616334 DOI： 10.1016/j.ccr.2006.03.003
Source DB: PubMed Journal: Cancer Cell ISSN： 1535-6108 Impact factor: 31.743