Literature DB >> 16614791

Hyperserotoninemia and altered immunity in autism.

Nancy K Burgess1, Thayne L Sweeten, William M McMahon, Robert S Fujinami.   

Abstract

One of the most consistent biological findings in autism is elevated whole blood serotonin (5-HT) levels found in about 1/3 of cases. Immune abnormalities are also commonly observed in this disorder. Given 5-HT's role as an immunomodulator, possible connections between 5-HT and immune abnormalities in autism are explored in this review. Areas of focus include hyperserotoninemia and cellular immune function, autoantibodies to 5-HT receptors, and 5-HT's role in autoimmunity. Further research is needed to determine the interactions between neuropsychiatric and immune dysfunction in autism and related disorders.

Entities:  

Mesh：

Substances：

Year:  2006        PMID： 16614791     DOI： 10.1007/s10803-006-0100-7

Source DB:  PubMed          Journal:  J Autism Dev Disord        ISSN： 0162-3257


  95 in total

1.  Autistic children and their first-degree relatives: relationships between serotonin and norepinephrine levels and intelligence.

Authors:  E H Cook; B L Leventhal; W Heller; J Metz; M Wainwright; D X Freedman
Journal:  J Neuropsychiatry Clin Neurosci       Date:  1990       Impact factor: 2.198

2.  Hyperserotoninemia and serotonin receptor antibodies in children with autism but not mental retardation.

Authors:  V K Singh; E A Singh; R P Warren
Journal:  Biol Psychiatry       Date:  1997-03-15       Impact factor: 13.382

3.  The role of mast cells in the elicitation of experimental allergic encephalomyelitis.

Authors:  G N Dietsch; D J Hinrichs
Journal:  J Immunol       Date:  1989-03-01       Impact factor: 5.422

4.  Evidence for an association with the serotonin transporter promoter region polymorphism and autism.

Authors:  N Yirmiya; T Pilowsky; L Nemanov; S Arbelle; T Feinsilver; I Fried; R P Ebstein
Journal:  Am J Med Genet       Date:  2001-05-08

5.  Possible association of the extended MHC haplotype B44-SC30-DR4 with autism.

Authors:  R P Warren; V K Singh; P Cole; J D Odell; C B Pingree; W L Warren; C W DeWitt; M McCullough
Journal:  Immunogenetics       Date:  1992       Impact factor: 2.846

6.  Enhancement of human natural killer cell cytotoxicity by serotonin: role of non-T/CD16+ NK cells, accessory monocytes, and 5-HT1A receptors.

Authors:  K Hellstrand; S Hermodsson
Journal:  Cell Immunol       Date:  1990-04-15       Impact factor: 4.868

7.  Brief report: autistic disorder in three children with cytomegalovirus infection.

Authors:  Thayne L Sweeten; David J Posey; Christopher J McDougle
Journal:  J Autism Dev Disord       Date:  2004-10

Review 8.  The amygdala and related structures in the pathophysiology of autism.

Authors:  Thayne L Sweeten; David J Posey; Anantha Shekhar; Christopher J McDougle
Journal:  Pharmacol Biochem Behav       Date:  2002-03       Impact factor: 3.533

9.  Modulation of chicken plaque-forming cells by serotonin and dopamine.

Authors:  R S Gray; F M McCorkle; K M Denno; R L Taylor
Journal:  Poult Sci       Date:  1991-07       Impact factor: 3.352

10.  Platelet 5-HT2 serotonin receptor binding sites in autistic children and their first-degree relatives.

Authors:  B D Perry; E H Cook; B L Leventhal; M S Wainwright; D X Freedman
Journal:  Biol Psychiatry       Date:  1991-07-15       Impact factor: 13.382
View more
  14 in total

1.  Macrophage migration inhibitory factor and autism spectrum disorders.

Authors:  Elena L Grigorenko; Summer S Han; Carolyn M Yrigollen; Lin Leng; Yuka Mizue; George M Anderson; Erik J Mulder; Annelies de Bildt; Ruud B Minderaa; Fred R Volkmar; Joseph T Chang; Richard Bucala
Journal:  Pediatrics       Date:  2008-08       Impact factor: 7.124

Review 2.  The serotonergic anatomy of the developing human medulla oblongata: implications for pediatric disorders of homeostasis.

Authors:  Hannah C Kinney; Kevin G Broadbelt; Robin L Haynes; Ingvar J Rognum; David S Paterson
Journal:  J Chem Neuroanat       Date:  2011-05-27       Impact factor: 3.052

3.  Studies on regeneration of central nervous system and social ability of the earthworm Eudrilus eugeniae.

Authors:  Nino Gopi Daisy; Elaiya Raja Subramanian; Jackson Durairaj Selvan Christyraj; Dinesh Kumar Sudalai Mani; Johnson Retnaraj Samuel Selvan Christyraj; Kalidas Ramamoorthy; Vaithilingaraja Arumugaswami; Sudhakar Sivasubramaniam
Journal:  Invert Neurosci       Date:  2016-06-09

4.  Investigation of signaling molecules and metabolites found in crustacean hemolymph via in vivo microdialysis using a multifaceted mass spectrometric platform.

Authors:  Shan Jiang; Zhidan Liang; Ling Hao; Lingjun Li
Journal:  Electrophoresis       Date:  2016-02-25       Impact factor: 3.535

Review 5.  Atypical antipsychotics in children with pervasive developmental disorders.

Authors:  Benjamin Chavez; Mapy Chavez-Brown; Michael A Sopko; Jose A Rey
Journal:  Paediatr Drugs       Date:  2007       Impact factor: 3.022

Review 6.  Pleiotropic effects of neurotransmission during development: modulators of modularity.

Authors:  Barbara L Thompson; Gregg D Stanwood
Journal:  J Autism Dev Disord       Date:  2008-07-22

7.  A lack of association between hyperserotonemia and the increased frequency of serum anti-myelin basic protein auto-antibodies in autistic children.

Authors:  Gehan Ahmed Mostafa; Laila Yousef Al-Ayadhi
Journal:  J Neuroinflammation       Date:  2011-06-22       Impact factor: 8.322

8.  Low serum IgA and increased expression of CD23 on B lymphocytes in peripheral blood in children with regressive autism aged 3-6 years old.

Authors:  Jolanta Wasilewska; Maciej Kaczmarski; Anna Stasiak-Barmuta; Jolanta Tobolczyk; Ewa Kowalewska
Journal:  Arch Med Sci       Date:  2012-05-09       Impact factor: 3.318

9.  Autism spectrum disorder causes, mechanisms, and treatments: focus on neuronal synapses.

Authors:  Hyejung Won; Won Mah; Eunjoon Kim
Journal:  Front Mol Neurosci       Date:  2013-08-05       Impact factor: 5.639

10.  Brief report: normal intestinal permeability at elevated platelet serotonin levels in a subgroup of children with pervasive developmental disorders in Curaçao (The Netherlands antilles).

Authors:  Ramses F J Kemperman; Fred D Muskiet; A Inge Boutier; Ido P Kema; Frits A J Muskiet
Journal:  J Autism Dev Disord       Date:  2007-07-28
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.