OBJECTIVE: To analyze the production of antibodies to polysaccharide antigens in patients with ataxia-telangiectasia. PATIENTS AND METHODS: We used the ELISA technique to measure the levels of IgG antibodies to serotypes 1, 3, 5, 6B, 9V and 14 of Streptococcus pneumoniae in 14 patients with ataxia-telangiectasia before and after immunization with 23-valent polysaccharide vaccine. Adequate response to individual polysaccharide can be defined as a postimmunization antibody titer equal to or greater than 1.3 microg/ml or as a minimum fourfold increase over the baseline (preimmunization) value. RESULTS: Six (43%) patients showed an absent response to all serotypes analyzed. Four patients showed adequate response to only one serotype, one patient to two serotypes, two patients to three serotypes and only one patient to four out of six serotypes analyzed. No patient had adequate response to all serotypes tested. Postimmunization pneumococcus IgG levels were higher than preimmunization levels to all serotypes analyzed, except for serotype 3. In spite of this, the mean postimmunization levels were lower than 1.3 microg/ml in all serotypes, except for serotype 14. Mean increment was less than four in all serotypes analyzed. CONCLUSIONS: Our results suggest that patients with ataxia-telangiectasia are at a high risk of having an impaired response to pneumococcus, which may be one of the causes of recurrent sinopulmonary infections in these patients.
OBJECTIVE: To analyze the production of antibodies to polysaccharide antigens in patients with ataxia-telangiectasia. PATIENTS AND METHODS: We used the ELISA technique to measure the levels of IgG antibodies to serotypes 1, 3, 5, 6B, 9V and 14 of Streptococcus pneumoniae in 14 patients with ataxia-telangiectasia before and after immunization with 23-valent polysaccharide vaccine. Adequate response to individual polysaccharide can be defined as a postimmunization antibody titer equal to or greater than 1.3 microg/ml or as a minimum fourfold increase over the baseline (preimmunization) value. RESULTS: Six (43%) patients showed an absent response to all serotypes analyzed. Four patients showed adequate response to only one serotype, one patient to two serotypes, two patients to three serotypes and only one patient to four out of six serotypes analyzed. No patient had adequate response to all serotypes tested. Postimmunization pneumococcus IgG levels were higher than preimmunization levels to all serotypes analyzed, except for serotype 3. In spite of this, the mean postimmunization levels were lower than 1.3 microg/ml in all serotypes, except for serotype 14. Mean increment was less than four in all serotypes analyzed. CONCLUSIONS: Our results suggest that patients with ataxia-telangiectasia are at a high risk of having an impaired response to pneumococcus, which may be one of the causes of recurrent sinopulmonary infections in these patients.
Authors: Sharon A McGrath-Morrow; W Adam Gower; Cynthia Rothblum-Oviatt; Alan S Brody; Claire Langston; Leland L Fan; Maureen A Lefton-Greif; Thomas O Crawford; Michelle Troche; John T Sandlund; Paul G Auwaerter; Blaine Easley; Gerald M Loughlin; John L Carroll; Howard M Lederman Journal: Pediatr Pulmonol Date: 2010-09
Authors: Otavio Cabral-Marques; Stefanie Klaver; Lena F Schimke; Évelyn H Ascendino; Taj Ali Khan; Paulo Vítor Soeiro Pereira; Angela Falcai; Alexander Vargas-Hernández; Leopoldo Santos-Argumedo; Liliana Bezrodnik; Ileana Moreira; Gisela Seminario; Daniela Di Giovanni; Andrea Gómez Raccio; Oscar Porras; Cristina Worm Weber; Janaíra Fernandes Ferreira; Fabiola Scancetti Tavares; Elisa de Carvalho; Claudia França Cavalcante Valente; Gisele Kuntze; Miguel Galicchio; Alejandra King; Nelson Augusto Rosário-Filho; Milena Baptistella Grota; Maria Marluce dos Santos Vilela; Regina Sumiko Watanabe Di Gesu; Simone Lima; Leiva de Souza Moura; Eduardo Talesnik; Eli Mansour; Pérsio Roxo-Junior; Juan Carlos Aldave; Ekaterine Goudouris; Fernanda Pinto-Mariz; Laura Berrón-Ruiz; Tamara Staines-Boone; Wilmer O Córdova Calderón; María del Carmen Zarate-Hernández; Anete S Grumach; Ricardo Sorensen; Anne Durandy; Troy R Torgerson; Beatriz Tavares Costa Carvalho; Francisco Espinosa-Rosales; Hans D Ochs; Antonio Condino-Neto Journal: J Clin Immunol Date: 2014-01-09 Impact factor: 8.317
Authors: Otavio Cabral-Marques; Lena-Friederike Schimke; Paulo Vítor Soeiro Pereira; Angela Falcai; João Bosco de Oliveira; Mary J Hackett; Paolo Ruggero Errante; Cristina Worm Weber; Janaíra Fernandes Ferreira; Gisele Kuntze; Nelson Augusto Rosário-Filho; Hans D Ochs; Troy R Torgerson; Beatriz Tavares Costa Carvalho; Antonio Condino-Neto Journal: J Clin Immunol Date: 2011-12-23 Impact factor: 8.317
Authors: Rachel Warren; William Domm; Min Yee; Andrew Campbell; Jane Malone; Terry Wright; Margot Mayer-Pröschel; Michael A O'Reilly Journal: Am J Physiol Lung Cell Mol Physiol Date: 2019-09-11 Impact factor: 5.464