| Literature DB >> 16613724 |
Najim A Al-Masoudi1, Iman A Al-Masoudi, Ibrahim A I Ali, Yaseen A Al-Soud, Bahjat Saeed, Paolo La Colla.
Abstract
A series of amino acid esters bearing coumarin (3-15) were synthesized and evaluated, in vitro, against HIV-1, and bovine viral diarrhea virus (BVDV). The in vitro cytotoxicity of 3-10 and 12 was assayed against a panel of tumor cell lines consisting of CD4 human T-cells. Compound 14 showed inhibition of HIV-1 with EC50 > 1.6 microg mL(-1), meanwhile compound 9 exhibited activity against leukaemia (MT4) with CC50 = 24 micromol L(-1).Entities:
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Year: 2006 PMID： 16613724
Source DB: PubMed Journal: Acta Pharm ISSN： 1330-0075 Impact factor: 2.230