Literature DB >> 1661367

A prototype beam delivery system for the proton medical accelerator at Loma Linda.

G Coutrakon1, M Bauman, D Lesyna, D Miller, J Nusbaum, J Slater, J Johanning, J Miranda, P M DeLuca, J Siebers.   

Abstract

A variable energy proton accelerator was commissioned at Fermi National Accelerator Laboratory for use in cancer treatment at the Loma Linda University Medical Center. The advantages of precise dose localization by proton therapy, while sparing nearby healthy tissue, are well documented [R. R. Wilson, Radiology 47, 487 (1946); M. Wagner, Med. Phys. 9, 749 (1982); M. Goitein and F. Chen, Med. Phys. 10, 831 (1983)]. One of the components of the proton therapy facility is a beam delivery system capable of delivering precise dose distributions to the target volume in the patient. To this end, a prototype beam delivery system was tested during the accelerator's commissioning period. The beam delivery system consisted of a beam spreading device to produce a large, uniform field, a range modulator to generate a spread out Bragg peak (SOBP), and various beam detectors to measure intensity, beam centering, and dose distributions. The beam delivery system provided a uniform proton dose distribution in a cylindrical volume of 20-cm-diam area and 9-cm depth. The dose variations throughout the target volume were found to be less than +/- 5%. Modifications in the range modulator should reduce this considerably. The central axis dose rate in the region of the SOBP was found to be 0.4 cGy/spill with an incident beam intensity of 6.7 x 10(9) protons/spill. With an accelerator repetition rate of 30 spills/min and expected intensity of 2.5 x 10(10) protons/spill for patient treatment, this system can provide 50 cGy/min for a 20-cm-diam field and 9-cm range modulation.(ABSTRACT TRUNCATED AT 250 WORDS)

Entities:  

Mesh:

Substances:

Year:  1991        PMID: 1661367     DOI: 10.1118/1.596617

Source DB:  PubMed          Journal:  Med Phys        ISSN: 0094-2405            Impact factor:   4.071


  5 in total

1.  Mechanism of hypocoagulability in proton-irradiated ferrets.

Authors:  Gabriel S Krigsfeld; Alexandria R Savage; Jenine K Sanzari; Andrew J Wroe; Daila S Gridley; Ann R Kennedy
Journal:  Int J Radiat Biol       Date:  2013-06-10       Impact factor: 2.694

2.  Segmental analysis of respiratory liver motion in patients with and without a history of abdominal surgery.

Authors:  Yasuhiro Shimizu; Shigeyuki Takamatsu; Kazutaka Yamamoto; Yoshikazu Maeda; Makoto Sasaki; Hiroyasu Tamamura; Sayuri Bou; Tomoyasu Kumano; Toshifumi Gabata
Journal:  Jpn J Radiol       Date:  2018-06-20       Impact factor: 2.374

3.  Initial testing of a pixelated silicon detector prototype in proton therapy.

Authors:  Andrew J Wroe; Grant McAuley; Anthony V Teran; Jeannie Wong; Marco Petasecca; Michael Lerch; James M Slater; Anatoly B Rozenfeld
Journal:  J Appl Clin Med Phys       Date:  2017-07-18       Impact factor: 2.102

4.  Evaluation of the dosimetric properties of a diode detector for small field proton radiosurgery.

Authors:  Grant A McAuley; Anthony V Teran; Jerry D Slater; James M Slater; Andrew J Wroe
Journal:  J Appl Clin Med Phys       Date:  2015-11-08       Impact factor: 2.102

5.  Proton-induced DNA damage promotes integration of foreign plasmid DNA into human genome.

Authors:  Meghri Katerji; Antonella Bertucci; Valery Filippov; Marcelo Vazquez; Xin Chen; Penelope J Duerksen-Hughes
Journal:  Front Oncol       Date:  2022-09-02       Impact factor: 5.738

  5 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.