Literature DB >> 1661244

GABAA receptor subtypes: from pharmacology to molecular biology.

D R Burt1, G L Kamatchi.   

Abstract

GABAA receptors are GABA (gamma-aminobutyric acid)-gated chloride channels, which are major mediators of neuronal inhibition in the brain and are modulated by benzodiazepines, barbiturates, alcohol, and other important centrally acting drugs. Although previous pharmacological and biochemical data had suggested a degree of heterogeneity, recent cloning of at least 15 different receptor subunits, thought to be combined in groups of five, indicates that the brain may contain a truly astonishing variety of GABAA receptor subtypes. This review describes the little that is known about these subtypes, emphasizing possible molecular bases of receptor heterogeneity. We also discuss approaches to establishing the subunit composition of subtypes.

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Year:  1991        PMID： 1661244     DOI： 10.1096/fasebj.5.14.1661244

Source DB:  PubMed          Journal:  FASEB J        ISSN： 0892-6638            Impact factor:   5.191


  60 in total

1.  Dual mode of stimulation by the beta-carboline ZK 91085 of recombinant GABA(A) receptor currents: molecular determinants affecting its action.

Authors:  U Thomet; R Baur; P Scholze; W Sieghart; E Sigel
Journal:  Br J Pharmacol       Date:  1999-07       Impact factor: 8.739

Review 2.  Regulation of ion channel expression in neural cells by hormones and growth factors.

Authors:  L J Chew; V Gallo
Journal:  Mol Neurobiol       Date:  1998-12       Impact factor: 5.590

Review 3.  Neurochemical and molecular pharmacological aspects of the GABA(B) receptor.

Authors:  K Kuriyama; M Hirouchi; H Kimura
Journal:  Neurochem Res       Date:  2000-10       Impact factor: 3.996

4.  Amygdala-specific reduction of alpha1-GABAA receptors disrupts the anticonvulsant, locomotor, and sedative, but not anxiolytic, effects of benzodiazepines in mice.

Authors:  Scott A Heldt; Kerry J Ressler
Journal:  J Neurosci       Date:  2010-05-26       Impact factor: 6.167

5.  "Anxiolytic" and "anxiogenic" benzodiazepines and beta-carbolines: effects on aggressive and social behavior in rats and squirrel monkeys.

Authors:  E M Weerts; W Tornatzky; K A Miczek
Journal:  Psychopharmacology (Berl)       Date:  1993       Impact factor: 4.530

6.  Homology modeling of human alpha 1 beta 2 gamma 2 and house fly beta 3 GABA receptor channels and Surflex-docking of fipronil.

Authors:  Jin Cheng; Xiu-Lian Ju; Xiang-Yang Chen; Gen-Yan Liu
Journal:  J Mol Model       Date:  2009-02-24       Impact factor: 1.810

7.  Pharmacological characterization of the homomeric and heteromeric UNC-49 GABA receptors in C. elegans.

Authors:  Bruce A Bamber; Roy E Twyman; Erik M Jorgensen
Journal:  Br J Pharmacol       Date:  2003-03       Impact factor: 8.739

8.  Differential expression of gamma-aminobutyric acid receptor A (GABA(A)) and effects of homocysteine.

Authors:  Neetu Tyagi; David Lominadze; William Gillespie; Karni S Moshal; Utpal Sen; Dorothea S Rosenberger; Mesia Steed; Suresh C Tyagi
Journal:  Clin Chem Lab Med       Date:  2007       Impact factor: 3.694

9.  Enhancement of GABAA receptor-mediated conductances induced by nerve injury in a subclass of sensory neurons.

Authors:  A A Oyelese; D L Eng; G B Richerson; J D Kocsis
Journal:  J Neurophysiol       Date:  1995-08       Impact factor: 2.714

10.  The modulatory action of loreclezole at the gamma-aminobutyric acid type A receptor is determined by a single amino acid in the beta 2 and beta 3 subunit.

Authors:  P B Wingrove; K A Wafford; C Bain; P J Whiting
Journal:  Proc Natl Acad Sci U S A       Date:  1994-05-10       Impact factor: 11.205
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