Literature DB >> 16612326

The multifaceted mismatch-repair system.

Josef Jiricny1.   

Abstract

By removing biosynthetic errors from newly synthesized DNA, mismatch repair (MMR) improves the fidelity of DNA replication by several orders of magnitude. Loss of MMR brings about a mutator phenotype, which causes a predisposition to cancer. But MMR status also affects meiotic and mitotic recombination, DNA-damage signalling, apoptosis and cell-type-specific processes such as class-switch recombination, somatic hypermutation and triplet-repeat expansion. This article reviews our current understanding of this multifaceted DNA-repair system in human cells.

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Year:  2006        PMID： 16612326     DOI： 10.1038/nrm1907

Source DB:  PubMed          Journal:  Nat Rev Mol Cell Biol        ISSN： 1471-0072            Impact factor:   94.444


  511 in total

1.  PTEN loss compromises homologous recombination repair in astrocytes: implications for glioblastoma therapy with temozolomide or poly(ADP-ribose) polymerase inhibitors.

Authors:  Brian McEllin; Cristel V Camacho; Bipasha Mukherjee; Brandon Hahm; Nozomi Tomimatsu; Robert M Bachoo; Sandeep Burma
Journal:  Cancer Res       Date:  2010-06-08       Impact factor: 12.701

2.  Human MSH2 (hMSH2) protein controls ATP processing by hMSH2-hMSH6.

Authors:  Christopher D Heinen; Jennifer L Cyr; Christopher Cook; Nidhi Punja; Miho Sakato; Robert A Forties; Juana Martin Lopez; Manju M Hingorani; Richard Fishel
Journal:  J Biol Chem       Date:  2011-09-19       Impact factor: 5.157

3.  Modulation of microRNA processing by mismatch repair protein MutLα.

Authors:  Guogen Mao; Sanghee Lee; Janice Ortega; Liya Gu; Guo-Min Li
Journal:  Cell Res       Date:  2012-01-31       Impact factor: 25.617

4.  Mismatch repair-dependent mutagenesis in nondividing cells.

Authors:  Gina P Rodriguez; Nina V Romanova; Gaobin Bao; N Cynthia Rouf; Yoke Wah Kow; Gray F Crouse
Journal:  Proc Natl Acad Sci U S A       Date:  2012-04-02       Impact factor: 11.205

5.  Chronic exposure to stress hormones promotes transformation and tumorigenicity of 3T3 mouse fibroblasts.

Authors:  Melanie S Flint; Andrew Baum; Britteny Episcopo; Kelly Z Knickelbein; Angela J Liegey Dougall; William H Chambers; Frank J Jenkins
Journal:  Stress       Date:  2012-05-16       Impact factor: 3.493

6.  PCNA function in the activation and strand direction of MutLα endonuclease in mismatch repair.

Authors:  Anna Pluciennik; Leonid Dzantiev; Ravi R Iyer; Nicoleta Constantin; Farid A Kadyrov; Paul Modrich
Journal:  Proc Natl Acad Sci U S A       Date:  2010-08-16       Impact factor: 11.205

7.  Constitutional mismatch repair-deficiency syndrome.

Authors:  Katharina Wimmer; Christian P Kratz
Journal:  Haematologica       Date:  2010-05       Impact factor: 9.941

8.  Differential correction of lagging-strand replication errors made by DNA polymerases {alpha} and {delta}.

Authors:  Stephanie A Nick McElhinny; Grace E Kissling; Thomas A Kunkel
Journal:  Proc Natl Acad Sci U S A       Date:  2010-11-01       Impact factor: 11.205

Review 9.  Chlamydomonas reinhardtii: a convenient model system for the study of DNA repair in photoautotrophic eukaryotes.

Authors:  Daniel Vlcek; Andrea Sevcovicová; Barbara Sviezená; Eliska Gálová; Eva Miadoková
Journal:  Curr Genet       Date:  2007-11-09       Impact factor: 3.886

10.  Significant associations of mismatch repair gene polymorphisms with clinical outcome of pancreatic cancer.

Authors:  Xiaoqun Dong; Li Jiao; Yanan Li; Douglas B Evans; Huamin Wang; Kenneth R Hess; James L Abbruzzese; Donghui Li
Journal:  J Clin Oncol       Date:  2009-02-23       Impact factor: 44.544
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