PURPOSE OF REVIEW: Following the recent progress mainly in the fields of genetics and neurobiology, the validity of the diagnostic distinction between schizophrenia and bipolar disorder is increasingly challenged. RECENT FINDINGS: Evidence for basic neurobiological processes common for both disorders is expanding with regard to (a) susceptibility genes, (b) neurodevelopment (for example myelination), and (c) brain functions (for example sensory gating, visuospatial achievement). Recent epidemiological studies also stress communalities. SUMMARY: The diagnostic split between schizophrenia and bipolar disorder is unable to define distinct etiological and/or pathophysiological entities.
PURPOSE OF REVIEW: Following the recent progress mainly in the fields of genetics and neurobiology, the validity of the diagnostic distinction between schizophrenia and bipolar disorder is increasingly challenged. RECENT FINDINGS: Evidence for basic neurobiological processes common for both disorders is expanding with regard to (a) susceptibility genes, (b) neurodevelopment (for example myelination), and (c) brain functions (for example sensory gating, visuospatial achievement). Recent epidemiological studies also stress communalities. SUMMARY: The diagnostic split between schizophrenia and bipolar disorder is unable to define distinct etiological and/or pathophysiological entities.
Authors: Erika Pedrosa; Radu Stefanescu; Benjamin Margolis; Oriana Petruolo; Yungtai Lo; Karen Nolan; Tomas Novak; Pavla Stopkova; Herbert M Lachman Journal: Schizophr Res Date: 2008-05-27 Impact factor: 4.939
Authors: Riccardo Zuliani; T William J Moorhead; Mark E Bastin; Eve C Johnstone; Stephen M Lawrie; Paolo Brambilla; Michael C O'Donovan; Michael J Owen; Jeremy Hall; Andrew M McIntosh Journal: Psychiatry Res Date: 2011-01-12 Impact factor: 3.222
Authors: Robin J Hennessy; Patrizia A Baldwin; David J Browne; Anthony Kinsella; John L Waddington Journal: Schizophr Res Date: 2010-05-31 Impact factor: 4.939
Authors: Xianjin Zhou; Wei Tang; Tiffany A Greenwood; Shengzhen Guo; Lin He; Mark A Geyer; John R Kelsoe Journal: PLoS One Date: 2009-04-09 Impact factor: 3.240