BACKGROUND: To examine whether linezolid, a new oxazolidinone antibiotic, has an effect on human polymorphonuclear leukocyte (PMN) function. METHODS: Flow-cytometric techniques for the demonstration of PMN chemotaxis towards zymosan-activated serum, and phagocytosis and respiratory burst after incubation in linezolid. RESULTS: Linezolid at concentrations of 10- 160 mg/l did not significantly influence PMN function as measured by chemotaxis, phagocytosis and respiratory burst. CONCLUSIONS: Linezolid at therapeutic or supratherapeutic concentrations does not influence human PMN function. This applies to the chemically pure substance as well as to the commercial preparation containing additives for intravenous infusion.
BACKGROUND: To examine whether linezolid, a new oxazolidinone antibiotic, has an effect on human polymorphonuclear leukocyte (PMN) function. METHODS: Flow-cytometric techniques for the demonstration of PMN chemotaxis towards zymosan-activated serum, and phagocytosis and respiratory burst after incubation in linezolid. RESULTS:Linezolid at concentrations of 10- 160 mg/l did not significantly influence PMN function as measured by chemotaxis, phagocytosis and respiratory burst. CONCLUSIONS:Linezolid at therapeutic or supratherapeutic concentrations does not influence human PMN function. This applies to the chemically pure substance as well as to the commercial preparation containing additives for intravenous infusion.
Authors: Stephen J Evans; Aled E L Roberts; Andrew Conway Morris; A John Simpson; Llinos G Harris; Dietrich Mack; Rowena E Jenkins; Thomas S Wilkinson Journal: Sci Rep Date: 2020-10-02 Impact factor: 4.379