BACKGROUND: Limited information exists regarding risk factors for reinfection after cure of Helicobacter pylori infection. AIM: To determine the 2-year reinfection rate of H. pylori in a cohort of urban Alaska Natives. METHODS: Participants over 18 years of age undergoing oesophagogastroduodenoscopy had (13)C urea breath test, culture, CLOtest and histology performed. Those diagnosed with H. pylori who tested urea breath test-negative at 8 weeks after treatment were followed prospectively at 4 months, 6 months, 1 year and 2 years. Subjects experiencing H. pylori reinfection as defined by a positive urea breath test were compared with those who did not become reinfected using univariable and multivariable analysis. Risk of reinfection over time was estimated by the Kaplan-Meier method. RESULTS: Helicobacter pylori reinfection occurred in 14 of 98 subjects successfully treated. The cumulative reinfection rate was 5.1% (95% CI: 0.7%-9.5%) at 4 months, 7.2% (2.0-12.3%) at 6 months, 10.3% (4.2-16.3%) at 1-year and 14.5% (7.5-21.6%) at 2 years. In multivariable analysis, a history of previous peptic ulcer disease or presence of ulcer at time of study oesophagogastroduodenoscopy were the only risk factors associated with reinfection (P = 0.01). CONCLUSIONS: Based on the findings from our study, subjects with a history of or current peptic ulcer disease should be followed, after successful treatment for H. pylori, with periodic urea breath test to detect reinfection, as reinfection would put them at high risk for ulcer recurrence.
BACKGROUND: Limited information exists regarding risk factors for reinfection after cure of Helicobacter pyloriinfection. AIM: To determine the 2-year reinfection rate of H. pylori in a cohort of urban Alaska Natives. METHODS:Participants over 18 years of age undergoing oesophagogastroduodenoscopy had (13)C urea breath test, culture, CLOtest and histology performed. Those diagnosed with H. pylori who tested urea breath test-negative at 8 weeks after treatment were followed prospectively at 4 months, 6 months, 1 year and 2 years. Subjects experiencing H. pylori reinfection as defined by a positive urea breath test were compared with those who did not become reinfected using univariable and multivariable analysis. Risk of reinfection over time was estimated by the Kaplan-Meier method. RESULTS:Helicobacter pylori reinfection occurred in 14 of 98 subjects successfully treated. The cumulative reinfection rate was 5.1% (95% CI: 0.7%-9.5%) at 4 months, 7.2% (2.0-12.3%) at 6 months, 10.3% (4.2-16.3%) at 1-year and 14.5% (7.5-21.6%) at 2 years. In multivariable analysis, a history of previous peptic ulcer disease or presence of ulcer at time of study oesophagogastroduodenoscopy were the only risk factors associated with reinfection (P = 0.01). CONCLUSIONS: Based on the findings from our study, subjects with a history of or current peptic ulcer disease should be followed, after successful treatment for H. pylori, with periodic urea breath test to detect reinfection, as reinfection would put them at high risk for ulcer recurrence.
Authors: Karen Miernyk; Julie Morris; Dana Bruden; Brian McMahon; Debby Hurlburt; Frank Sacco; Alan Parkinson; Thomas Hennessy; Michael Bruce Journal: J Clin Microbiol Date: 2011-07-13 Impact factor: 5.948
Authors: Adrienne H Tveit; Michael G Bruce; Dana L Bruden; Julie Morris; Alisa Reasonover; Debby A Hurlburt; Thomas W Hennessy; Brian McMahon Journal: J Clin Microbiol Date: 2011-08-03 Impact factor: 5.948
Authors: Dana L Bruden; Michael G Bruce; Karen M Miernyk; Julie Morris; Debby Hurlburt; Thomas W Hennessy; Helen Peters; Frank Sacco; Alan J Parkinson; Brian J McMahon Journal: World J Gastroenterol Date: 2011-11-14 Impact factor: 5.742
Authors: Karen M Miernyk; Dana L Bruden; Michael G Bruce; Brian J McMahon; Thomas W Hennessy; Helen V Peters; Debby A Hurlburt; Frank Sacco; Alan J Parkinson Journal: Clin Vaccine Immunol Date: 2006-11-01
Authors: Karen Miernyk; Dana Bruden; Carolyn Zanis; Brian McMahon; Frank Sacco; Thomas Hennessy; Alan Parkinson; Michael Bruce Journal: Helicobacter Date: 2013-01-15 Impact factor: 5.753
Authors: Kum Hei Ryu; Sun Young Yi; Youn Ju Na; Su Jung Baik; Su Jin Yoon; Hae-Sun Jung; Hyun Joo Song Journal: World J Gastroenterol Date: 2010-01-14 Impact factor: 5.742