Literature DB >> 16611219

Synthetic diether-linked cationic lipids for gene delivery.

Dongliang Liu1, Weihong Qiao, Zongshi Li, Shubiao Zhang, Lvbo Cheng, Kun Jin.   

Abstract

Quaternary ammonium lipids 2a-p, with diether linkages between hydrocarbon chains and their ammonium headgroups, were synthesized as potential vectors for cationic liposome-mediated gene delivery. Varying the length of carbon chains and quaternary ammonium heads as well as different anionic complexes will enable the study of the structure-function relationships of these cationic lipids in terms of gene delivery properties.

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Year:  2006        PMID： 16611219     DOI： 10.1111/j.1747-0285.2006.00366.x

Source DB:  PubMed          Journal:  Chem Biol Drug Des        ISSN： 1747-0277            Impact factor:   2.817


  2 in total

1.  Effect of spacer attachment sites and pH-sensitive headgroup expansion on cationic lipid-mediated gene delivery of three novel myristoyl derivatives.

Authors:  Michael Spelios; Sean Nedd; Nikita Matsunaga; Michalakis Savva
Journal:  Biophys Chem       Date:  2007-05-31       Impact factor: 2.352

2.  The discovery and enhanced properties of trichain lipids in lipopolyplex gene delivery systems.

Authors:  Atefeh Mohammadi; Laila Kudsiova; M Firouz Mohd Mustapa; Frederick Campbell; Danielle Vlaho; Katharina Welser; Harriet Story; Aristides D Tagalakis; Stephen L Hart; David J Barlow; Alethea B Tabor; M Jayne Lawrence; Helen C Hailes
Journal:  Org Biomol Chem       Date:  2019-01-23       Impact factor: 3.876
  2 in total

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