STUDY POPULATION: We examined the relationship between chronic fatigue syndrome (CFS) and allostatic load in a population-based, case-control study of 43 CFS patients and 60 nonfatigued, healthy controls from Wichita, KS, USA. METHODS: An allostatic load index was computed for all study participants using available laboratory and clinical data, according to a standard algorithm for allostatic load. Logistic regression analysis was used to compute odds ratios (ORs) as estimates of relative risk in models that included adjustment for matching factors and education; 95% confidence intervals (CIs) were computed to estimate the precision of the ORs. RESULTS: CFS patients were 1.9-times more likely to have a high allostatic load index than controls (95% CI = 0.75, 4.75) after adjusting for education level, in addition to matching factors. The strength of this association increased in a linear trend across categories of low, medium and high levels of allostatic load (p = 0.06). CONCLUSION: CFS was associated with a high level of allostatic load. The three allostatic load components that best discriminated cases from controls were waist:hip ratio, aldosterone and urinary cortisol.
STUDY POPULATION: We examined the relationship between chronic fatigue syndrome (CFS) and allostatic load in a population-based, case-control study of 43 CFS patients and 60 nonfatigued, healthy controls from Wichita, KS, USA. METHODS: An allostatic load index was computed for all study participants using available laboratory and clinical data, according to a standard algorithm for allostatic load. Logistic regression analysis was used to compute odds ratios (ORs) as estimates of relative risk in models that included adjustment for matching factors and education; 95% confidence intervals (CIs) were computed to estimate the precision of the ORs. RESULTS: CFS patients were 1.9-times more likely to have a high allostatic load index than controls (95% CI = 0.75, 4.75) after adjusting for education level, in addition to matching factors. The strength of this association increased in a linear trend across categories of low, medium and high levels of allostatic load (p = 0.06). CONCLUSION: CFS was associated with a high level of allostatic load. The three allostatic load components that best discriminated cases from controls were waist:hip ratio, aldosterone and urinary cortisol.
Authors: Olga A Sukocheva; Rebekah Maksoud; Narasimha M Beeraka; SabbaRao V Madhunapantula; Mikhail Sinelnikov; Vladimir N Nikolenko; Margarita E Neganova; Sergey G Klochkov; Mohammad Amjad Kamal; Donald R Staines; Sonya Marshall-Gradisnik Journal: J Adv Res Date: 2021-11-26 Impact factor: 12.822
Authors: Begoña Ruiz-Núñez; Rabab Tarasse; Emar F Vogelaar; D A Janneke Dijck-Brouwer; Frits A J Muskiet Journal: Front Endocrinol (Lausanne) Date: 2018-03-20 Impact factor: 5.555
Authors: Roumiana S Boneva; Jin-Mann S Lin; Friedrich Wieser; Urs M Nater; Beate Ditzen; Robert N Taylor; Elizabeth R Unger Journal: Front Pediatr Date: 2019-05-21 Impact factor: 3.418
Authors: Paul A Sandifer; Landon C Knapp; Tracy K Collier; Amanda L Jones; Robert-Paul Juster; Christopher R Kelble; Richard K Kwok; John V Miglarese; Lawrence A Palinkas; Dwayne E Porter; Geoffrey I Scott; Lisa M Smith; William C Sullivan; Ariana E Sutton-Grier Journal: Geohealth Date: 2017-03-06