HSFs in development.

Heat shock transcription factors, as well as heat shock proteins, are involved in different steps in differentiation and development, in addition to their role in adaptation to stress. This has already been demonstrated in the case of the single heat shock factor present in Drosophila. Over the last 6 years, similar observations have accumulated from the progressive inactivation of the different hsf genes in mammals, the use of double-null animals, and the slow characterization of their complex phenotypes. Although these studies are not yet complete, the data so far can be used to draw some conclusions. All hsf genes contribute to development in mammals and to normal functions at the adult stage, by controlling the expression of Hsp and non-Hsp genes. Reproduction, the immune response and aging are the processes that are the most deeply affected. An attractive hypothesis would be that these new functions have been recruited during evolution in order to coordinate these processes: HSFs may occupy a central place in the trade off that organisms make between reproduction and maintenance, in response to the variations in the environment.