| Literature DB >> 16608289 |
Xiaohui Li1, Kathryn G Klemic, Mark A Reed, Fred J Sigworth.
Abstract
We present a microfluidic system integrated with disposable cell interface partitions for simultaneous patch clamp recordings. Glass-supported poly(dimethylsiloxane) (PDMS) partitions, having a 2 microm air-blown aperture, were reversibly sealed to a microfluidic system including PDMS channels with isolation valves and microfabricated Ag/AgCl electrodes. Gigaseal recordings from RBL-1 cells were obtained with a 24% success rate. Simultaneous whole cell recordings from valve-isolated electrodes were obtained.Entities:
Mesh：
Year: 2006 PMID： 16608289 DOI： 10.1021/nl060165r
Source DB: PubMed Journal: Nano Lett ISSN： 1530-6984 Impact factor: 11.189