In vitro studies toward noninvasive glucose monitoring with optical coherence tomography.

We use optical coherence tomography (OCT) to measure glucose-induced changes in Intralipid and in mouse skin samples in vitro. Mouse skin samples are cultured in a CO2 incubator before measurements are made with different amounts of added glucose concentrations. The results show that the glucose-induced changes in the OCT slope value vary between 20% and 52%/30 mM glucose in different mouse skin samples. This change is much larger than the change in 2% Intralipid (2.1%/30 mM) and in 5% Intralipid (0.86%/30 mM). Hence the results show that OCT has potential to monitor glucose-induced changes in tissues in vitro.