OBJECTIVE: Body mass index (BMI) is associated with increased incidence of cardiovascular disease (CVD). However, the risk could be very different for individuals with the same body mass. The present study explored whether regional fat distribution, as measured by waist-hip ratio (WHR), could modify the impact of BMI on the risk of CVD in men and women. DESIGN: Prospective population-based study. SUBJECTS: A total of 10 369 men and 16 638 women, 45-73 years old, from general population in Malmö, Sweden. MEASUREMENTS: All subjects were followed over 7 years for the incidences of first-ever cardiac event (CE) and ischemic stroke in relation to BMI category (<25.0, 25.0-29.9, > or =30.0) and WHR. RESULTS: The prevalence of overweight and obesity was 39.4 and 13.0%, respectively. During follow-up, 1280 subjects suffered a CVD event (750 CE, 530 ischemic stroke). The risk of CVD in women increased with increasing levels of WHR, irrespective of BMI category. In men, WHR (per 1 s.d. increase) was associated with increased incidence of CVD in those with normal weight (relative risk (RR)=1.24; 95% CI: 1.13-1.37) after adjustments for confounding factors. However, WHR was not related to CVD in overweight men (RR=1.06; 95%CI: 0.94-1.20) or obese men (RR=1.04; 95%CI: 0.87-1.24). A significant interaction was observed between sex and WHR on the CVD risk. CONCLUSION: The effect of WHR on incidence of CVD is modified by the overall body weight and by gender. WHR adds prognostic information on the cardiovascular risk in women at all levels of BMI, and in men with normal weight.
OBJECTIVE: Body mass index (BMI) is associated with increased incidence of cardiovascular disease (CVD). However, the risk could be very different for individuals with the same body mass. The present study explored whether regional fat distribution, as measured by waist-hip ratio (WHR), could modify the impact of BMI on the risk of CVD in men and women. DESIGN: Prospective population-based study. SUBJECTS: A total of 10 369 men and 16 638 women, 45-73 years old, from general population in Malmö, Sweden. MEASUREMENTS: All subjects were followed over 7 years for the incidences of first-ever cardiac event (CE) and ischemic stroke in relation to BMI category (<25.0, 25.0-29.9, > or =30.0) and WHR. RESULTS: The prevalence of overweight and obesity was 39.4 and 13.0%, respectively. During follow-up, 1280 subjects suffered a CVD event (750 CE, 530 ischemic stroke). The risk of CVD in women increased with increasing levels of WHR, irrespective of BMI category. In men, WHR (per 1 s.d. increase) was associated with increased incidence of CVD in those with normal weight (relative risk (RR)=1.24; 95% CI: 1.13-1.37) after adjustments for confounding factors. However, WHR was not related to CVD in overweight men (RR=1.06; 95%CI: 0.94-1.20) or obesemen (RR=1.04; 95%CI: 0.87-1.24). A significant interaction was observed between sex and WHR on the CVD risk. CONCLUSION: The effect of WHR on incidence of CVD is modified by the overall body weight and by gender. WHR adds prognostic information on the cardiovascular risk in women at all levels of BMI, and in men with normal weight.
Authors: Tiffany L Cox; Jamy D Ard; T Mark Beasley; Jose R Fernandez; Virginia J Howard; Olivia Affuso Journal: J Womens Health (Larchmt) Date: 2011-08-04 Impact factor: 2.681
Authors: Jessica Fitzpatrick; Stephen M Sozio; Bernard G Jaar; Mara A McAdams-DeMarco; Michelle M Estrella; Larisa G Tereshchenko; Jose M Monroy-Trujillo; Rulan S Parekh Journal: Am J Nephrol Date: 2018-11-14 Impact factor: 3.754
Authors: L de Koning; H C Gerstein; J Bosch; R Diaz; V Mohan; G Dagenais; S Yusuf; S S Anand Journal: Diabetologia Date: 2010-04-07 Impact factor: 10.122
Authors: Antonios Stavropoulos-Kalinoglou; Giorgos S Metsios; Yiannis Koutedakis; Alan M Nevill; Karen M Douglas; Athanasios Jamurtas; Jet J C S Veldhuijzen van Zanten; Mourad Labib; George D Kitas Journal: Ann Rheum Dis Date: 2007-02-08 Impact factor: 19.103
Authors: Jose R Medina-Inojosa; John A Batsis; Marta Supervia; Virend K Somers; Randal J Thomas; Sarah Jenkins; Chassidy Grimes; Francisco Lopez-Jimenez Journal: Am J Cardiol Date: 2018-02-02 Impact factor: 2.778
Authors: Joep Perk; Guy De Backer; Helmut Gohlke; Ian Graham; Zeljko Reiner; W M Monique Verschuren; Christian Albus; Pascale Benlian; Gudrun Boysen; Renata Cifkova; Christi Deaton; Shah Ebrahim; Miles Fisher; Giuseppe Germano; Richard Hobbs; Arno Hoes; Sehnaz Karadeniz; Alessandro Mezzani; Eva Prescott; Lars Ryden; Martin Scherer; Mikko Syvänne; Wilma J M Scholte Op Reimer; Christiaan Vrints; David Wood; Jose Luis Zamorano; Faiez Zannad Journal: Int J Behav Med Date: 2012-12