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Literature DB >> 16607014

Acanthamoeba castellanii promotion of in vitro survival and transmission of coxsackie b3 viruses.

A Mattana¹, C Serra, E Mariotti, G Delogu, P L Fiori, P Cappuccinelli.

Abstract

This work was undertaken to determine whether Acanthamoeba could play a role in the survival and transmission of coxsackieviruses and focused on in vitro interactions between Acanthamoeba castellanii and coxsackie B3 viruses (CVB-3). Residual virus titer evaluations and immunofluorescence experiments revealed a remarkable CVB-3 adsorption on amoeba surfaces and accumulation inside cells. The survival of viruses was independent of the dynamics of amoeba replication and encystment. In addition, our results indicated that virus-infected amoebas can release infectious viruses during interaction with human macrophages. On the basis of these data, Acanthamoeba appears to be a potential promoter of the survival of coxsackieviruses and their transmission to human hosts.

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Year: 2006 PMID： 16607014 PMCID： PMC1459673 DOI： 10.1128/EC.5.4.665-671.2006

Source DB: PubMed Journal: Eukaryot Cell ISSN： 1535-9786

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