| Literature DB >> 16606934 |
P H Gordon1, C Doorish, J Montes, R L Mosley, R L Mosely, B Diamond, R B Macarthur, L H Weimer, P Kaufmann, A P Hays, L P Rowland, H E Gendelman, S Przedborski, H Mitsumoto.
Abstract
The authors conducted a randomized controlled trial to test the safety and immunology of glatiramer acetate in ALS. Twenty treated patients were randomly assigned to daily or biweekly injections. Ten control patients were selected from another trial and followed up concurrently. Injection reactions were the only common adverse event (p = 0.01). Treated patients showed enhanced lymphocyte proliferation (p = 0.02). The safety profile and immune effects support conducting larger trials of dose selection and efficacy.Entities:
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Year: 2006 PMID： 16606934 DOI： 10.1212/01.wnl.0000204235.81272.e2
Source DB: PubMed Journal: Neurology ISSN： 0028-3878 Impact factor: 9.910