Literature DB >> 16606930

Opioidergic changes in the pineal gland and hypothalamus in cluster headache: a ligand PET study.

T Sprenger1, F Willoch, M Miederer, F Schindler, M Valet, A Berthele, M E Spilker, S Förderreuther, A Straube, I Stangier, H J Wester, T R Tölle.   

Abstract

Using PET with the opioidergic ligand [11C]diprenorphine, the authors demonstrate decreased tracer binding in the pineal gland of cluster headache patients vs healthy volunteers. Opioid receptor availability in the hypothalamus and cingulate cortex depended on the duration of the headache disorder. Therefore, the pathophysiology of cluster headache may relate to opioidergic dysfunction in circuitries generating the biologic clock.

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Year:  2006        PMID： 16606930     DOI： 10.1212/01.wnl.0000204225.15947.f8

Source DB:  PubMed          Journal:  Neurology        ISSN： 0028-3878            Impact factor:   9.910


  23 in total

1.  Successful prophylactic treatment of chronic cluster headache with low-dose levomethadone.

Authors:  T Sprenger; C L Seifert; M Miederer; M Valet; T R Tölle
Journal:  J Neurol       Date:  2008-08-04       Impact factor: 4.849

Review 2.  Licit and illicit drug use in cluster headache.

Authors:  Amelie Govare; Elizabeth Leroux
Journal:  Curr Pain Headache Rep       Date:  2014-05

Review 3.  The pathophysiology of the trigeminal autonomic cephalalgias, with clinical implications.

Authors:  Mads C J Barloese
Journal:  Clin Auton Res       Date:  2017-09-23       Impact factor: 4.435

Review 4.  Sex-based differences in brain alterations across chronic pain conditions.

Authors:  Arpana Gupta; Emeran A Mayer; Connor Fling; Jennifer S Labus; Bruce D Naliboff; Jui-Yang Hong; Lisa A Kilpatrick
Journal:  J Neurosci Res       Date:  2017-01-02       Impact factor: 4.164

Review 5.  Physiopathology of Migraine: What Have We Learned from Functional Imaging?

Authors:  Antonio Russo; Marcello Silvestro; Gioacchino Tedeschi; Alessandro Tessitore
Journal:  Curr Neurol Neurosci Rep       Date:  2017-10-23       Impact factor: 5.081

Review 6.  Personalized medicine and opioid analgesic prescribing for chronic pain: opportunities and challenges.

Authors:  Stephen Bruehl; A Vania Apkarian; Jane C Ballantyne; Ann Berger; David Borsook; Wen G Chen; John T Farrar; Jennifer A Haythornthwaite; Susan D Horn; Michael J Iadarola; Charles E Inturrisi; Lixing Lao; Sean Mackey; Jianren Mao; Andrea Sawczuk; George R Uhl; James Witter; Clifford J Woolf; Jon-Kar Zubieta; Yu Lin
Journal:  J Pain       Date:  2013-02       Impact factor: 5.820

Review 7.  New insights into headache: an update on functional and structural imaging findings.

Authors:  Arne May
Journal:  Nat Rev Neurol       Date:  2009-04       Impact factor: 42.937

Review 8.  [Neuropathic pain. How to open the blackbox].

Authors:  C Maier; R Baron; C Sommer
Journal:  Schmerz       Date:  2015-10       Impact factor: 1.107

Review 9.  [Trigeminal autonomic cephalgias. After initial diagnosis, consider secondary causes].

Authors:  M Rosenberg-Nordmann; A Berthele; T R Tölle; T Sprenger
Journal:  Nervenarzt       Date:  2009-12       Impact factor: 1.214

Review 10.  [Positron emission tomography in pain research. From the structure to the activity of the opiate receptor system].

Authors:  T Sprenger; G Henriksen; M Valet; S Platzer; A Berthele; T R Tölle
Journal:  Schmerz       Date:  2007-11       Impact factor: 1.107
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