Literature DB >> 16606927

Alpha-synuclein pathology in the spinal cords of neurologically asymptomatic aged individuals.

K J Klos1, J E Ahlskog, K A Josephs, H Apaydin, J E Parisi, B F Boeve, M W DeLucia, D W Dickson.   

Abstract

The authors assessed the frequency of spinal cord alpha-synuclein pathology in neurologically asymptomatic individuals older than 60 years of age (N = 106). Using alpha-synuclein immunohistochemistry, nine cases (8%) had incidental Lewy neurites in the intermediolateral column and at least some alpha-synuclein pathology in the dorsal motor nucleus of the vagus, locus ceruleus, and central raphe nucleus. Sparse alpha-synuclein pathology was also detected in the substantia nigra, basal forebrain, amygdala, or cortex in all but two cases.

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Year:  2006        PMID： 16606927     DOI： 10.1212/01.wnl.0000204179.88955.fa

Source DB:  PubMed          Journal:  Neurology        ISSN： 0028-3878            Impact factor:   9.910


  47 in total

1.  Prevalence of Submandibular Gland Synucleinopathy in Parkinson's Disease, Dementia with Lewy Bodies and other Lewy Body Disorders.

Authors:  Thomas G Beach; Charles H Adler; Geidy Serrano; Lucia I Sue; D G Walker; Brittany N Dugger; Holly A Shill; Erika Driver-Dunckley; John N Caviness; Anthony Intorcia; Jessica Filon; Sarah Scott; Angelica Garcia; Brittany Hoffman; Christine M Belden; Kathryn J Davis; Marwan N Sabbagh
Journal:  J Parkinsons Dis       Date:  2016       Impact factor: 5.568

2.  Incidental Lewy body disease: do some cases represent a preclinical stage of dementia with Lewy bodies?

Authors:  Roberta Frigerio; Hiroshige Fujishiro; Tae-Beom Ahn; Keith A Josephs; Demetrius M Maraganore; Anthony DelleDonne; Joseph E Parisi; Kevin J Klos; Bradley F Boeve; Dennis W Dickson; J Eric Ahlskog
Journal:  Neurobiol Aging       Date:  2009-06-26       Impact factor: 4.673

3.  Comparison of risk factor profiles in incidental Lewy body disease and Parkinson disease.

Authors:  Roberta Frigerio; Hiroshige Fujishiro; Demetrius M Maraganore; Kevin J Klos; Anthony DelleDonne; Michael G Heckman; Julia E Crook; Keith A Josephs; Joseph E Parisi; Bradley F Boeve; Dennis W Dickson; J Eric Ahlskog
Journal:  Arch Neurol       Date:  2009-09

4.  Seniors with Parkinson's disease: initial medical treatment.

Authors:  J Eric Ahlskog
Journal:  J Clin Neurol       Date:  2010-12-31       Impact factor: 3.077

Review 5.  Neuropathology of Parkinson disease.

Authors:  Dennis W Dickson
Journal:  Parkinsonism Relat Disord       Date:  2017-08-01       Impact factor: 4.891

6.  Spinal cord involvement in Lewy body-related α-synucleinopathies.

Authors:  Raffaele Nardone; Yvonne Höller; Francesco Brigo; Viviana Versace; Luca Sebastianelli; Cristina Florea; Kerstin Schwenker; Stefan Golaszewski; Leopold Saltuari; Eugen Trinka
Journal:  J Spinal Cord Med       Date:  2019-01-08       Impact factor: 1.985

7.  Calpain inhibition protected spinal cord motoneurons against 1-methyl-4-phenylpyridinium ion and rotenone.

Authors:  S Samantaray; V H Knaryan; C Le Gal; S K Ray; N L Banik
Journal:  Neuroscience       Date:  2011-06-22       Impact factor: 3.590

Review 8.  Brain Banking for Research into Neurodegenerative Disorders and Ageing.

Authors:  Claire E Shepherd; Holly Alvendia; Glenda M Halliday
Journal:  Neurosci Bull       Date:  2019-01-02       Impact factor: 5.203

9.  Medical records documentation of constipation preceding Parkinson disease: A case-control study.

Authors:  R Savica; J M Carlin; B R Grossardt; J H Bower; J E Ahlskog; D M Maraganore; A E Bharucha; W A Rocca
Journal:  Neurology       Date:  2009-11-24       Impact factor: 9.910

10.  Genetic neuropathology of Parkinson's disease.

Authors:  Mark R Cookson; John Hardy; Patrick A Lewis
Journal:  Int J Clin Exp Pathol       Date:  2008-01-01
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