PURPOSE: The expression of pigment epithelium-derived factor (PEDF), a strong inhibitor of angiogenesis, has not been examined in human ocular fibrovascular membranes, to the best of our knowledge. The purpose of this study was to determine whether PEDF is expressed in the fibrovascular membranes in eyes of patients with proliferative diabetic retinopathy (PDR), and to compare the expression of PEDF with that of vascular endothelial growth factor (VEGF). METHODS: The expression of PEDF and VEGF in the fibrovascular membranes excised during vitreous surgery in eight cases of PDR was determined by immunohistochemistry. RESULTS: VEGF was strongly expressed in the endothelial cells of newly formed vessels in the fibrovascular membranes. In contrast, PEDF was weakly expressed in the endothelial cells and was prominently expressed in the extracellular matrix and fibrous tissue surrounding the new vessels. CONCLUSIONS: Our results suggest that PEDF, along with VEGF, may modulate the formation of fibrovascular membranes in patients with PDR.
PURPOSE: The expression of pigment epithelium-derived factor (PEDF), a strong inhibitor of angiogenesis, has not been examined in human ocular fibrovascular membranes, to the best of our knowledge. The purpose of this study was to determine whether PEDF is expressed in the fibrovascular membranes in eyes of patients with proliferative diabetic retinopathy (PDR), and to compare the expression of PEDF with that of vascular endothelial growth factor (VEGF). METHODS: The expression of PEDF and VEGF in the fibrovascular membranes excised during vitreous surgery in eight cases of PDR was determined by immunohistochemistry. RESULTS: VEGF was strongly expressed in the endothelial cells of newly formed vessels in the fibrovascular membranes. In contrast, PEDF was weakly expressed in the endothelial cells and was prominently expressed in the extracellular matrix and fibrous tissue surrounding the new vessels. CONCLUSIONS: Our results suggest that PEDF, along with VEGF, may modulate the formation of fibrovascular membranes in patients with PDR.
Authors: N Ogata; J Tombran-Tink; M Nishikawa; T Nishimura; Y Mitsuma; T Sakamoto; M Matsumura Journal: Am J Ophthalmol Date: 2001-09 Impact factor: 5.258
Authors: Sahng Yeon Kim; Carmen Mocanu; D Scott Mcleod; Imran A Bhutto; Carol Merges; Mark Eid; Patrick Tong; Gerard A Lutty Journal: Exp Eye Res Date: 2003-10 Impact factor: 3.467
Authors: Kyoungmin Park; Kyungwon Lee; Bin Zhang; Ti Zhou; Xi He; Guoquan Gao; Anne R Murray; Jian-Xing Ma Journal: Mol Cell Biol Date: 2011-05-16 Impact factor: 4.272