Literature DB >> 16604305

Possible association between nonsynonymous polymorphisms of the anaplastic lymphoma kinase (ALK) gene and schizophrenia in a Japanese population.

H Kunugi1, R Hashimoto, T Okada, H Hori, T Nakabayashi, A Baba, K Kudo, M Omori, S Takahashi, R Tsukue, K Anami, N Hirabayashi, A Kosuga, M Tatsumi, K Kamijima, T Asada, S Harada, K Arima, O Saitoh.   

Abstract

We examined, for the first time, the possible association between schizophrenia and the anaplastic lymphoma kinase (ALK) gene which plays an important role in neurodevelopment. When two nonsynonymous polymorphisms (Arg1491Lys and Glu1529Asp) were examined, there were significant differences in genotype and allele distributions between patients and controls. Individuals homozygous for the minor allele (1491Lys-1529Asp) were more common in patients than in controls (p = 0.0064, odds ratio 2.4, 95% CI 1.3-4.6). These results suggest that genetic variations of the ALK gene might confer susceptibility to schizophrenia.

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Year:  2006        PMID： 16604305     DOI： 10.1007/s00702-006-0436-3

Source DB:  PubMed          Journal:  J Neural Transm (Vienna)        ISSN： 0300-9564            Impact factor:   3.575


  18 in total

1.  Novel polymorphisms in the promoter region of the neurotrophin-3 gene and their associations with schizophrenia.

Authors:  Mineko Hattori; Hiroshi Kunugi; Akihisa Akahane; Hiroshi Tanaka; Sugiko Ishida; Tetsuya Hirose; Ryoji Morita; Kazuhiro Yamakawa; Shinichiro Nanko
Journal:  Am J Med Genet       Date:  2002-04-08

2.  Brain-derived neurotrophic factor gene and schizophrenia: polymorphism screening and association analysis.

Authors:  Shinichiro Nanko; Hiroshi Kunugi; Hideto Hirasawa; Norihiro Kato; Toru Nabika; Shotai Kobayashi
Journal:  Schizophr Res       Date:  2003-08-01       Impact factor: 4.939

Review 3.  Neurotrophic factors and the maldevelopmental hypothesis of schizophrenic psychoses. Review article.

Authors:  J Thome; P Foley; P Riederer
Journal:  J Neural Transm (Vienna)       Date:  1998       Impact factor: 3.575

4.  ALK, the chromosome 2 gene locus altered by the t(2;5) in non-Hodgkin's lymphoma, encodes a novel neural receptor tyrosine kinase that is highly related to leukocyte tyrosine kinase (LTK)

Authors:  S W Morris; C Naeve; P Mathew; P L James; M N Kirstein; X Cui; D P Witte
Journal:  Oncogene       Date:  1997-05-08       Impact factor: 9.867

5.  Molecular characterization of ALK, a receptor tyrosine kinase expressed specifically in the nervous system.

Authors:  T Iwahara; J Fujimoto; D Wen; R Cupples; N Bucay; T Arakawa; S Mori; B Ratzkin; T Yamamoto
Journal:  Oncogene       Date:  1997-01-30       Impact factor: 9.867

6.  Midkine binds to anaplastic lymphoma kinase (ALK) and acts as a growth factor for different cell types.

Authors:  Gerald E Stoica; Angera Kuo; Ciaran Powers; Emma T Bowden; Elaine Buchert Sale; Anna T Riegel; Anton Wellstein
Journal:  J Biol Chem       Date:  2002-07-16       Impact factor: 5.157

Review 7.  Thalamic dysfunction in schizophrenia: neurochemical, neuropathological, and in vivo imaging abnormalities.

Authors:  Sarah M Clinton; James H Meador-Woodruff
Journal:  Schizophr Res       Date:  2004-08-01       Impact factor: 4.939

8.  Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in non-Hodgkin's lymphoma.

Authors:  S W Morris; M N Kirstein; M B Valentine; K G Dittmer; D N Shapiro; D L Saltman; A T Look
Journal:  Science       Date:  1994-03-04       Impact factor: 47.728

Review 9.  Midkine and pleiotrophin in neural development and cancer.

Authors:  Kenji Kadomatsu; Takashi Muramatsu
Journal:  Cancer Lett       Date:  2004-02-20       Impact factor: 8.679

Review 10.  Neurotrophic factors and the pathophysiology of schizophrenic psychoses.

Authors:  Nuria Durany; Johannes Thome
Journal:  Eur Psychiatry       Date:  2004-09       Impact factor: 5.361
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  6 in total

Review 1.  Anaplastic lymphoma kinase: role in cancer pathogenesis and small-molecule inhibitor development for therapy.

Authors:  Thomas R Webb; Jake Slavish; Rani E George; A Thomas Look; Liquan Xue; Qin Jiang; Xiaoli Cui; Walter B Rentrop; Stephan W Morris
Journal:  Expert Rev Anticancer Ther       Date:  2009-03       Impact factor: 4.512

2.  The receptor tyrosine kinase Alk controls neurofibromin functions in Drosophila growth and learning.

Authors:  Jean Y Gouzi; Anastasios Moressis; James A Walker; Anthi A Apostolopoulou; Ruth H Palmer; André Bernards; Efthimios M C Skoulakis
Journal:  PLoS Genet       Date:  2011-09-15       Impact factor: 5.917

3.  An evolutionary conserved role for anaplastic lymphoma kinase in behavioral responses to ethanol.

Authors:  Amy W Lasek; Jana Lim; Christopher L Kliethermes; Karen H Berger; Geoff Joslyn; Gerry Brush; Liquan Xue; Margaret Robertson; Monica S Moore; Karen Vranizan; Stephan W Morris; Marc A Schuckit; Raymond L White; Ulrike Heberlein
Journal:  PLoS One       Date:  2011-07-22       Impact factor: 3.240

4.  A Peptide Link Between Human Cytomegalovirus Infection, Neuronal Migration, and Psychosis.

Authors:  Guglielmo Lucchese; Agnes Flöel; Benjamin Stahl
Journal:  Front Psychiatry       Date:  2020-05-08       Impact factor: 4.157

5.  NPM-ALK: The Prototypic Member of a Family of Oncogenic Fusion Tyrosine Kinases.

Authors:  Joel D Pearson; Jason K H Lee; Julinor T C Bacani; Raymond Lai; Robert J Ingham
Journal:  J Signal Transduct       Date:  2012-07-18

6.  Anaplastic Lymphoma Kinase Is a Regulator of Alcohol Consumption and Excitatory Synaptic Plasticity in the Nucleus Accumbens Shell.

Authors:  Regina A Mangieri; Esther Y Maier; Tavanna R Buske; Amy W Lasek; Richard A Morrisett
Journal:  Front Pharmacol       Date:  2017-08-15       Impact factor: 5.810
  6 in total

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