Literature DB >> 16604206

Interception of quorum sensing in Staphylococcus aureus: a new niche for peptidomimetics.

Benjamin C Gorske1, Helen E Blackwell.   

Abstract

Pathogenesis in Staphylococcus aureus is dependent on local cell density and is regulated in part by small macrocyclic peptides. Natural and artificial peptide inhibitors of this quorum sensing response have been synthesized and evaluated in structure-activity relationship studies. These investigations have illuminated the quorum sensing mechanism and set the stage for the design of biostable, peptidomimetic inhibitors that could be developed ultimately as therapeutics.

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Year:  2006        PMID： 16604206     DOI： 10.1039/b517681f

Source DB:  PubMed          Journal:  Org Biomol Chem        ISSN： 1477-0520            Impact factor:   3.876


  8 in total

Review 1.  Peptide signaling in the staphylococci.

Authors:  Matthew Thoendel; Jeffrey S Kavanaugh; Caralyn E Flack; Alexander R Horswill
Journal:  Chem Rev       Date:  2010-12-21       Impact factor: 60.622

2.  Structure-Guided Biochemical Analysis of Quorum Signal Synthase Specificities.

Authors:  Shi-Hui Dong; Mila Nhu-Lam; Rajesh Nagarajan; Satish K Nair
Journal:  ACS Chem Biol       Date:  2020-05-13       Impact factor: 5.100

3.  Simplified AIP-II Peptidomimetics Are Potent Inhibitors of Staphylococcus aureus AgrC Quorum Sensing Receptors.

Authors:  Joseph K Vasquez; Yftah Tal-Gan; Gabriel Cornilescu; Kimberly A Tyler; Helen E Blackwell
Journal:  Chembiochem       Date:  2017-01-20       Impact factor: 3.164

4.  Colostrum hexasaccharide, a novel Staphylococcus aureus quorum-sensing inhibitor.

Authors:  A Srivastava; B N Singh; D Deepak; A K S Rawat; B R Singh
Journal:  Antimicrob Agents Chemother       Date:  2015-02-02       Impact factor: 5.191

5.  N-phenylacetanoyl-L-homoserine lactones can strongly antagonize or superagonize quorum sensing in Vibrio fischeri.

Authors:  Grant D Geske; Jennifer C O'Neill; Helen E Blackwell
Journal:  ACS Chem Biol       Date:  2007-05-04       Impact factor: 5.100

6.  Modulation of bacterial quorum sensing with synthetic ligands: systematic evaluation of N-acylated homoserine lactones in multiple species and new insights into their mechanisms of action.

Authors:  Grant D Geske; Jennifer C O'Neill; David M Miller; Margrith E Mattmann; Helen E Blackwell
Journal:  J Am Chem Soc       Date:  2007-10-10       Impact factor: 15.419

Review 7.  Structure-function relationships in peptoids: recent advances toward deciphering the structural requirements for biological function.

Authors:  Sarah A Fowler; Helen E Blackwell
Journal:  Org Biomol Chem       Date:  2009-02-11       Impact factor: 3.876

8.  Quorumpeps database: chemical space, microbial origin and functionality of quorum sensing peptides.

Authors:  Evelien Wynendaele; Antoon Bronselaer; Joachim Nielandt; Matthias D'Hondt; Sofie Stalmans; Nathalie Bracke; Frederick Verbeke; Christophe Van De Wiele; Guy De Tré; Bart De Spiegeleer
Journal:  Nucleic Acids Res       Date:  2012-11-24       Impact factor: 16.971
  8 in total

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