Literature DB >> 16603354

4-(Aminoalkylamino)-3-benzimidazole-quinolinones as potent CHK-1 inhibitors.

Zhi-Jie Ni1, Paul Barsanti, Nathan Brammeier, Anthony Diebes, Daniel J Poon, Simon Ng, Sabina Pecchi, Keith Pfister, Paul A Renhowe, Savithri Ramurthy, Allan S Wagman, Dirksen E Bussiere, Vincent Le, Yasheen Zhou, Johanna M Jansen, Sylvia Ma, Thomas G Gesner.   

Abstract

CHK-1 is one of the key enzymes regulating checkpoints in cellular growth cycles. Novel 4-(amino-alkylamino)-3-benzimidazole-quinolinones were prepared and assayed for their ability to inhibit CHK-1. These compounds are potent cell permeable CHK-1 inhibitors and showed synergistic effect with a DNA-damaging agent, camptothecin.

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Year:  2006        PMID： 16603354     DOI： 10.1016/j.bmcl.2006.03.059

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  14 in total

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2.  Structure-based and shape-complemented pharmacophore modeling for the discovery of novel checkpoint kinase 1 inhibitors.

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4.  Efficient Hit-to-Lead Searching of Kinase Inhibitor Chemical Space via Computational Fragment Merging.

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5.  Synthesis of Constrained Heterocycles Employing Two Post-Ugi Cyclization Methods for Rapid Library Generation with In Cellulo Activity.

Authors:  Nicholas McConnell; Zhigang Xu; Vishnu Kumarasamy; Daekyu Sun; Brendan Frett; Hong-Yu Li
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6.  The intra-S-phase checkpoint affects both DNA replication initiation and elongation: single-cell and -DNA fiber analyses.

Authors:  Jennifer A Seiler; Chiara Conti; Ali Syed; Mirit I Aladjem; Yves Pommier
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Review 7.  Imidazoles as potential anticancer agents.

Authors:  Imran Ali; Mohammad Nadeem Lone; Haasan Y Aboul-Enein
Journal:  Medchemcomm       Date:  2017-04-13       Impact factor: 3.597

8.  Combining docking-based comparative intermolecular contacts analysis and k-nearest neighbor correlation for the discovery of new check point kinase 1 inhibitors.

Authors:  Nour Jamal Jaradat; Mohammad A Khanfar; Maha Habash; Mutasem Omar Taha
Journal:  J Comput Aided Mol Des       Date:  2015-05-09       Impact factor: 3.686

9.  Identification of potent Yes1 kinase inhibitors using a library screening approach.

Authors:  Paresma R Patel; Hongmao Sun; Samuel Q Li; Min Shen; Javed Khan; Craig J Thomas; Mindy I Davis
Journal:  Bioorg Med Chem Lett       Date:  2013-05-29       Impact factor: 2.823

10.  Limited nucleotide pools restrict Epstein-Barr virus-mediated B-cell immortalization.

Authors:  A Y Hafez; J E Messinger; K McFadden; G Fenyofalvi; C N Shepard; G M Lenzi; B Kim; M A Luftig
Journal:  Oncogenesis       Date:  2017-06-12       Impact factor: 7.485
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