Literature DB >> 16603352

Design and structure-activity relationship of 3-benzimidazol-2-yl-1H-indazoles as inhibitors of receptor tyrosine kinases.

Christopher M McBride1, Paul A Renhowe, Carla Heise, Johanna M Jansen, Gena Lapointe, Sylvia Ma, Ramon Piñeda, Jayesh Vora, Marion Wiesmann, Cynthia M Shafer.   

Abstract

3-Benzimidazol-2-yl-1H-indazole analogs were developed as inhibitors of receptor tyrosine kinases (RTK). The synthesis and SAR of this series is reported.

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Year:  2006        PMID: 16603352     DOI: 10.1016/j.bmcl.2006.03.069

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN: 0960-894X            Impact factor:   2.823


  3 in total

1.  One-pot diastreoselective synthesis of highly functionalized cyclohexenones: 2-oxo-N,4,6-triarylcyclohex-3-enecarboxamides.

Authors:  Mir Rasul Mousavi; Malek Taher Maghsoodlou; Sayyed Mostafa Habibi-Khorassani
Journal:  Mol Divers       Date:  2014-08-06       Impact factor: 2.943

2.  Combinatorial Pharmacophore-Based 3D-QSAR Analysis and Virtual Screening of FGFR1 Inhibitors.

Authors:  Nannan Zhou; Yuan Xu; Xian Liu; Yulan Wang; Jianlong Peng; Xiaomin Luo; Mingyue Zheng; Kaixian Chen; Hualiang Jiang
Journal:  Int J Mol Sci       Date:  2015-06-11       Impact factor: 5.923

3.  An optimized procedure for direct access to 1H-indazole-3-carboxaldehyde derivatives by nitrosation of indoles.

Authors:  Arnaud Chevalier; Abdelaaziz Ouahrouch; Alexandre Arnaud; Thibault Gallavardin; Xavier Franck
Journal:  RSC Adv       Date:  2018-04-09       Impact factor: 3.361

  3 in total

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