Literature DB >> 16603351

A pyrimidine-pyrazolone nucleoside chimera with potent in vitro anti-orthopoxvirus activity.

Xuesen Fan1, Xinying Zhang, Longhu Zhou, Kathy A Keith, Earl R Kern, Paul F Torrence.   

Abstract

Synthetic hybridization of two privileged drug scaffolds, pyrazolone on the one hand and pyrimidine nucleoside on the other, resulted in the generation of two novel 5-substituted pyrimidine nucleosides with potent in vitro antiviral activity against two representative orthopoxviruses, vaccinia virus and cowpox virus.

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Year:  2006        PMID： 16603351     DOI： 10.1016/j.bmcl.2006.03.043

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  12 in total

1.  Synthesis and antiviral activities of new acyclic and "double-headed" nucleoside analogues.

Authors:  Xinying Zhang; Adel Amer; Xuesen Fan; Jan Balzarini; Johan Neyts; Erik De Clercq; Mark Prichard; Earl Kern; Paul F Torrence
Journal:  Bioorg Chem       Date:  2006-12-02       Impact factor: 5.275

2.  Toward orthopoxvirus countermeasures: a novel heteromorphic nucleoside of unusual structure.

Authors:  Xuesen Fan; Xinying Zhang; Longhu Zhou; Kathy A Keith; Mark N Prichard; Earl R Kern; Paul F Torrence
Journal:  J Med Chem       Date:  2006-07-13       Impact factor: 7.446

3.  Selective phosphorylation of antiviral drugs by vaccinia virus thymidine kinase.

Authors:  Mark N Prichard; Kathy A Keith; Mary P Johnson; Emma A Harden; Alexis McBrayer; Ming Luo; Shihong Qiu; Debasish Chattopadhyay; Xuesen Fan; Paul F Torrence; Earl R Kern
Journal:  Antimicrob Agents Chemother       Date:  2007-02-26       Impact factor: 5.191

4.  Ionic liquid promoted preparation of 4H-thiopyran and pyrimidine nucleoside-thiopyran hybrids through one-pot multi-component reaction of thioamide.

Authors:  Xinying Zhang; Xiaoyan Li; Xuesen Fan; Xia Wang; Dongfang Li; Guirong Qu; Jianji Wang
Journal:  Mol Divers       Date:  2008-12-09       Impact factor: 2.943

5.  Synthesis, in-vitro antimicrobial and antitubercular screening of Schiff bases of 3-amino-1-phenyl-4- [2-(4-phenyl-1,3-thiazol-2-yl) hydrazin-1-ylidene]-4,5-dihydro-1H-pyrazol-5-one.

Authors:  K K Sivakumar; A Rajasekaran
Journal:  J Pharm Bioallied Sci       Date:  2013-04

6.  Antiviral Activity of 4'-thioIDU and Thymidine Analogs against Orthopoxviruses.

Authors:  Mark N Prichard; Earl R Kern
Journal:  Viruses       Date:  2010-09-16       Impact factor: 5.818

Review 7.  Drug Development against Smallpox: Present and Future.

Authors:  Déborah Delaune; Frédéric Iseni
Journal:  Antimicrob Agents Chemother       Date:  2020-03-24       Impact factor: 5.938

Review 8.  Pyrazolone structural motif in medicinal chemistry: Retrospect and prospect.

Authors:  Zefeng Zhao; Xufen Dai; Chenyang Li; Xiao Wang; Jiale Tian; Ying Feng; Jing Xie; Cong Ma; Zhuang Nie; Peinan Fan; Mingcheng Qian; Xirui He; Shaoping Wu; Yongmin Zhang; Xiaohui Zheng
Journal:  Eur J Med Chem       Date:  2019-11-16       Impact factor: 6.514

9.  Ionic liquid-promoted multi-component reaction: novel and efficient preparation of pyrazolo[3,4-b]pyridinone, pyrazolo[3,4-b]-quinolinone and their hybrids with pyrimidine nucleoside.

Authors:  Xinying Zhang; Dongfang Li; Xuesen Fan; Xia Wang; Xiaoyan Li; Guirong Qu; Jianji Wang
Journal:  Mol Divers       Date:  2009-06-12       Impact factor: 3.364

10.  3-Oxo-N',2-diphenyl-2,3-di-hydro-1H-pyrazole-4-carbohydrazide.

Authors:  Joel T Mague; Shaaban K Mohamed; Mehmet Akkurt; Eman A Ahmed; Mustafa R Albayati
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2014-06-25
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