BACKGROUND: Osteoblast-derived matrix metalloproteinse-1 (MMP-1), MMP-2 and tissue inhibitor of metalloproteinase-1 (TIMP-1) play a role in bone metabolism by degrading bone matrix. METHODS: We measured MMP-1, MMMP-2, TIMP-1 and associated results with age and bone metabolism in 591 Chinese women aged 20-80 y. RESULTS: Serum MMP-1, MMP-2, and TIMP-1 concentrations exhibited positive correlation with age. Serum concentrations of MMP-1 were higher in 40-69 y old women. The concentrations of MMP-2 were significantly increased in the 50-69 y olds. Serum TIMP-1 concentrations were significantly lower in women aged 30-59 y, and then these were followed by an increase at >60 y olds. We found a significant negative weaker correlation between MMP-2 and BMD. But multiple linear stepwise regression analysis showed that MMP-2 was not a determinant factor for BMD. There were significant positive correlations between MMP-2 and bone alkaline phosphatase (BAP), osteocalcin (OC), and cross-linked N-telopeptides of type I collagen (NTX). CONCLUSIONS: The serum concentrations of MMP-1, MMP-2, and TIMP-1 exhibit age-related changes, and circulating MMP-2 and bone turnover are related.
BACKGROUND: Osteoblast-derived matrix metalloproteinse-1 (MMP-1), MMP-2 and tissue inhibitor of metalloproteinase-1 (TIMP-1) play a role in bone metabolism by degrading bone matrix. METHODS: We measured MMP-1, MMMP-2, TIMP-1 and associated results with age and bone metabolism in 591 Chinese women aged 20-80 y. RESULTS: Serum MMP-1, MMP-2, and TIMP-1 concentrations exhibited positive correlation with age. Serum concentrations of MMP-1 were higher in 40-69 y old women. The concentrations of MMP-2 were significantly increased in the 50-69 y olds. Serum TIMP-1 concentrations were significantly lower in women aged 30-59 y, and then these were followed by an increase at >60 y olds. We found a significant negative weaker correlation between MMP-2 and BMD. But multiple linear stepwise regression analysis showed that MMP-2 was not a determinant factor for BMD. There were significant positive correlations between MMP-2 and bone alkaline phosphatase (BAP), osteocalcin (OC), and cross-linked N-telopeptides of type I collagen (NTX). CONCLUSIONS: The serum concentrations of MMP-1, MMP-2, and TIMP-1 exhibit age-related changes, and circulating MMP-2 and bone turnover are related.
Authors: Gregory J Tranah; Brent C Taylor; Li-Yung Lui; Joseph M Zmuda; Jane A Cauley; Kristine E Ensrud; Teresa A Hillier; Marc C Hochberg; Jia Li; Brian K Rhees; Henry A Erlich; Mark D Sternlicht; Gary Peltz; Steven R Cummings Journal: Calcif Tissue Int Date: 2008-09-12 Impact factor: 4.333
Authors: Yu-Ching Cheng; Wen-Hong L Kao; Braxton D Mitchell; Jeffrey R O'Connell; Haiqing Shen; Patrick F McArdle; Quince Gibson; Kathleen A Ryan; Alan R Shuldiner; Toni I Pollin Journal: Circ Cardiovasc Genet Date: 2009-05-14
Authors: Mareen Braunstein; Thomas Kusmenkov; Wolf Mutschler; Christian Kammerlander; Wolfgang Böcker; Viktoria Bogner-Flatz Journal: J Immunol Res Date: 2020-03-09 Impact factor: 4.818