BACKGROUND: Although major depressive disorder (MDD) represents one of the most serious psychiatric problems afflicting adolescents, efforts to understand the neural circuitry of adolescent MDD have lagged behind those of adult MDD. This study tests the hypothesis that adolescent MDD is associated with abnormal amygdala activity during evocative-face viewing. METHODS: Using functional magnetic resonance imaging (fMRI), between-group differences among MDD (n = 10), anxious (n = 11), and non-psychiatric comparisons (n = 23) were examined during successful vs. unsuccessful face encoding, with encoding success measured post-scan. RESULTS: Compared to healthy adolescents, MDD patients exhibited poorer memory for faces. fMRI analyses accounted for this performance difference through event-related methods. In an analysis comparing successful vs. unsuccessful face encoding, MDD patients exhibited greater left amygdala activation relative to healthy and anxious youth. CONCLUSIONS: Given prior findings among adults, this study suggests that adolescent and adult MDD may involve similar underlying abnormalities in amygdala functioning.
BACKGROUND: Although major depressive disorder (MDD) represents one of the most serious psychiatric problems afflicting adolescents, efforts to understand the neural circuitry of adolescent MDD have lagged behind those of adult MDD. This study tests the hypothesis that adolescent MDD is associated with abnormal amygdala activity during evocative-face viewing. METHODS: Using functional magnetic resonance imaging (fMRI), between-group differences among MDD (n = 10), anxious (n = 11), and non-psychiatric comparisons (n = 23) were examined during successful vs. unsuccessful face encoding, with encoding success measured post-scan. RESULTS: Compared to healthy adolescents, MDDpatients exhibited poorer memory for faces. fMRI analyses accounted for this performance difference through event-related methods. In an analysis comparing successful vs. unsuccessful face encoding, MDDpatients exhibited greater left amygdala activation relative to healthy and anxious youth. CONCLUSIONS: Given prior findings among adults, this study suggests that adolescent and adult MDD may involve similar underlying abnormalities in amygdala functioning.
Authors: Greg Perlman; Alan N Simmons; Jing Wu; Kevin S Hahn; Susan F Tapert; Jeffrey E Max; Martin P Paulus; Gregory G Brown; Guido K Frank; Laura Campbell-Sills; Tony T Yang Journal: J Affect Disord Date: 2012-03-07 Impact factor: 4.839
Authors: Françoise S Maheu; Mary Dozier; Amanda E Guyer; Darcy Mandell; Elizabeth Peloso; Kaitlin Poeth; Jessica Jenness; Jennifer Y F Lau; John P Ackerman; Daniel S Pine; Monique Ernst Journal: Cogn Affect Behav Neurosci Date: 2010-03 Impact factor: 3.282
Authors: Deanna M Barch; Michael S Gaffrey; Kelly N Botteron; Andrew C Belden; Joan L Luby Journal: Biol Psychiatry Date: 2012-07-07 Impact factor: 13.382
Authors: Erin B McClure; Abby Adler; Christopher S Monk; Jennifer Cameron; Samantha Smith; Eric E Nelson; Ellen Leibenluft; Monique Ernst; Daniel S Pine Journal: Psychopharmacology (Berl) Date: 2006-09-14 Impact factor: 4.530
Authors: Jennifer Y F Lau; David Goldman; Beata Buzas; Stephen J Fromm; Amanda E Guyer; Colin Hodgkinson; Christopher S Monk; Eric E Nelson; Pei-Hong Shen; Daniel S Pine; Monique Ernst Journal: Biol Psychiatry Date: 2008-10-31 Impact factor: 13.382
Authors: Etienne Sibille; Yingjie Wang; Jennifer Joeyen-Waldorf; Chris Gaiteri; Alexandre Surget; Sunghee Oh; Catherine Belzung; George C Tseng; David A Lewis Journal: Am J Psychiatry Date: 2009-07-15 Impact factor: 18.112