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Literature DB >> 16601923

Discovery of the molecular machinery CERT for endoplasmic reticulum-to-Golgi trafficking of ceramide.

Abstract

Synthesis and sorting of lipids are essential events for membrane biogenesis and its homeostasis. Ceramide is synthesised at the endoplasmic reticulum (ER), and translocated to the Golgi compartment for conversion to sphingomyelin (SM). We have recently identified a key factor (named CERT) for ceramide trafficking. In this short review, I summarise recent advances in molecular mechanisms of intracellular transport of ceramide, focusing on our genetic and biochemical approaches to this issue.

Entities: Chemical Gene

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Year: 2006 PMID： 16601923 DOI： 10.1007/s11010-005-9044-z

Source DB: PubMed Journal: Mol Cell Biochem ISSN： 0300-8177 Impact factor: 3.396

45 in total

Review 1. De novo sphingolipid biosynthesis: a necessary, but dangerous, pathway.

Authors: Alfred H Merrill
Journal: J Biol Chem Date: 2002-05-13 Impact factor: 5.157

2. Reduction of sphingomyelin level without accumulation of ceramide in Chinese hamster ovary cells affects detergent-resistant membrane domains and enhances cellular cholesterol efflux to methyl-beta -cyclodextrin.

Authors: M Fukasawa; M Nishijima; H Itabe; T Takano; K Hanada
Journal: J Biol Chem Date: 2000-11-03 Impact factor: 5.157

Review 3. StAR-related lipid transfer (START) proteins: mediators of intracellular lipid metabolism.

Authors: Raymond E Soccio; Jan L Breslow
Journal: J Biol Chem Date: 2003-04-30 Impact factor: 5.157

4. Cell biology: earthworms and lipid couriers.

Authors: Sean Munro
Journal: Nature Date: 2003-12-18 Impact factor: 49.962

5. Semi-intact cells permeable to macromolecules: use in reconstitution of protein transport from the endoplasmic reticulum to the Golgi complex.

Authors: C J Beckers; D S Keller; W E Balch
Journal: Cell Date: 1987-08-14 Impact factor: 41.582

Review 6. Sphingolipid transport in eukaryotic cells.

Authors: G van Meer; J C Holthuis
Journal: Biochim Biophys Acta Date: 2000-06-26

7. Identification of pleckstrin-homology-domain-containing proteins with novel phosphoinositide-binding specificities.

Authors: S Dowler; R A Currie ; D G Campbell ; M Deak; G Kular; C P Downes; D R Alessi
Journal: Biochem J Date: 2000-10-01 Impact factor: 3.857

8. Identification of a family of animal sphingomyelin synthases.

Authors: Klazien Huitema; Joep van den Dikkenberg; Jos F H M Brouwers; Joost C M Holthuis
Journal: EMBO J Date: 2003-12-18 Impact factor: 11.598

Review 9. ABC transporter architecture and mechanism: implications from the crystal structures of BtuCD and BtuF.

Authors: Kaspar P Locher; Elizabeth Borths
Journal: FEBS Lett Date: 2004-04-30 Impact factor: 4.124

Review 10. Intracellular cholesterol transport.

Authors: Raymond E Soccio; Jan L Breslow
Journal: Arterioscler Thromb Vasc Biol Date: 2004-05-06 Impact factor: 8.311

29 in total

Review 1. Lipid transport in the lactating mammary gland.

Authors: James L McManaman
Journal: J Mammary Gland Biol Neoplasia Date: 2014-02-25 Impact factor: 2.673

2. Phosphoregulation of the ceramide transport protein CERT at serine 315 in the interaction with VAMP-associated protein (VAP) for inter-organelle trafficking of ceramide in mammalian cells.

Authors: Keigo Kumagai; Miyuki Kawano-Kawada; Kentaro Hanada
Journal: J Biol Chem Date: 2014-02-25 Impact factor: 5.157

3. Sphingolipid transfer proteins defined by the GLTP-fold.

Authors: Lucy Malinina; Dhirendra K Simanshu; Xiuhong Zhai; Valeria R Samygina; RaviKanth Kamlekar; Roopa Kenoth; Borja Ochoa-Lizarralde; Margarita L Malakhova; Julian G Molotkovsky; Dinshaw J Patel; Rhoderick E Brown
Journal: Q Rev Biophys Date: 2015-03-23 Impact factor: 5.318

Discovery of the molecular machinery CERT for endoplasmic reticulum-to-Golgi trafficking of ceramide.

Review 1. De novo sphingolipid biosynthesis: a necessary, but dangerous, pathway.

2. Reduction of sphingomyelin level without accumulation of ceramide in Chinese hamster ovary cells affects detergent-resistant membrane domains and enhances cellular cholesterol efflux to methyl-beta -cyclodextrin.

Review 3. StAR-related lipid transfer (START) proteins: mediators of intracellular lipid metabolism.

4. Cell biology: earthworms and lipid couriers.

5. Semi-intact cells permeable to macromolecules: use in reconstitution of protein transport from the endoplasmic reticulum to the Golgi complex.

Review 6. Sphingolipid transport in eukaryotic cells.

7. Identification of pleckstrin-homology-domain-containing proteins with novel phosphoinositide-binding specificities.

8. Identification of a family of animal sphingomyelin synthases.

Review 9. ABC transporter architecture and mechanism: implications from the crystal structures of BtuCD and BtuF.

Review 10. Intracellular cholesterol transport.

Review 1. Lipid transport in the lactating mammary gland.

2. Phosphoregulation of the ceramide transport protein CERT at serine 315 in the interaction with VAMP-associated protein (VAP) for inter-organelle trafficking of ceramide in mammalian cells.

3. Sphingolipid transfer proteins defined by the GLTP-fold.

Review 4. Ceramidases, roles in sphingolipid metabolism and in health and disease.

Review 5. Sterols and sphingolipids: dynamic duo or partners in crime?

Review 6. Sphingolipids and mitochondrial apoptosis.

Review 7. Ceramide transfer protein and cancer.

8. Acute perturbations in Golgi organization impact de novo sphingomyelin synthesis.

9. Ceramide transfer protein function is essential for normal oxidative stress response and lifespan.

Review 10. Sphingolipids and membrane biology as determined from genetic models.