OBJECTIVES: To clarify the causes of death of residents with renal tubular dysfunction induced by cadmium (Cd) in the environment. METHODS: A 15 year follow up study was performed with the inhabitants living in the Cd polluted Kakehashi River basin in Japan. Standardised mortality ratios (SMRs) for causes of death, classified by ICD-9, were computed using the person-years method to investigate the excess mortality of subjects with urinary beta2-MG (microglobulin) > or =1000 microg/gCr. Mortality risk analysis was performed using Cox's proportional model to compare mortality between subjects with urinary beta2-MG > or =1000 and <1000 microg/gCr, and to investigate the relationship between the degree of urinary beta2-MG and mortality. RESULTS: Excess mortality due to heart failure and cerebral infarction in both sexes, and nephritis and nephrosis in men, was observed among subjects with urinary beta2-MG > or =1000 microg/gCr. Significant increases in mortality risk for cerebral infarction in men and for malignant neoplasms in women with urinary beta2-MG > or =1000 microg/gCr were observed during the first five year observation period. For nephritis and nephrosis, the mortality risks for men and women with urinary beta2-MG > or =1000 microg/gCr significantly increased over the 15 year observation period. The mortality risks for heart failure and cerebral infarction increased in proportion to the increased urinary beta2-MG in both sexes. Increased mortality risks for nephritis and nephrosis were identified in the subjects with urinary beta2-MG > or =10000 microg/gCr in both sexes. CONCLUSION: Renal tubular dysfunction induced by Cd affected the causes of death, and mortality for heart failure, cerebral infarction, and nephritis and nephrosis was increased among inhabitants living in a Cd polluted area in Japan. In women, cancer mortality may have been increased while Cd pollution was ongoing.
OBJECTIVES: To clarify the causes of death of residents with renal tubular dysfunction induced by cadmium (Cd) in the environment. METHODS: A 15 year follow up study was performed with the inhabitants living in the Cd polluted Kakehashi River basin in Japan. Standardised mortality ratios (SMRs) for causes of death, classified by ICD-9, were computed using the person-years method to investigate the excess mortality of subjects with urinary beta2-MG (microglobulin) > or =1000 microg/gCr. Mortality risk analysis was performed using Cox's proportional model to compare mortality between subjects with urinary beta2-MG > or =1000 and <1000 microg/gCr, and to investigate the relationship between the degree of urinary beta2-MG and mortality. RESULTS: Excess mortality due to heart failure and cerebral infarction in both sexes, and nephritis and nephrosis in men, was observed among subjects with urinary beta2-MG > or =1000 microg/gCr. Significant increases in mortality risk for cerebral infarction in men and for malignant neoplasms in women with urinary beta2-MG > or =1000 microg/gCr were observed during the first five year observation period. For nephritis and nephrosis, the mortality risks for men and women with urinary beta2-MG > or =1000 microg/gCr significantly increased over the 15 year observation period. The mortality risks for heart failure and cerebral infarction increased in proportion to the increased urinary beta2-MG in both sexes. Increased mortality risks for nephritis and nephrosis were identified in the subjects with urinary beta2-MG > or =10000 microg/gCr in both sexes. CONCLUSION:Renal tubular dysfunction induced by Cd affected the causes of death, and mortality for heart failure, cerebral infarction, and nephritis and nephrosis was increased among inhabitants living in a Cd polluted area in Japan. In women, cancer mortality may have been increased while Cd pollution was ongoing.
Authors: P Elliott; R Arnold; S Cockings; N Eaton; L Järup; J Jones; M Quinn; M Rosato; I Thornton; M Toledano; E Tristan; J Wakefield Journal: Occup Environ Med Date: 2000-02 Impact factor: 4.402
Authors: H Nakagawa; M Nishijo; Y Morikawa; M Tabata; M Senma; Y Kitagawa; S Kawano; M Ishizaki; N Sugita; M Nishi Journal: Arch Environ Health Date: 1993 Nov-Dec
Authors: Tim Nawrot; Michelle Plusquin; Janneke Hogervorst; Harry A Roels; Hilde Celis; Lutgarde Thijs; Jaco Vangronsveld; Etienne Van Hecke; Jan A Staessen Journal: Lancet Oncol Date: 2006-02 Impact factor: 41.316
Authors: Ana Navas-Acien; Ellen K Silbergeld; Richey Sharrett; Emma Calderon-Aranda; Elizabeth Selvin; Eliseo Guallar Journal: Environ Health Perspect Date: 2005-02 Impact factor: 9.031
Authors: Clara G Sears; Melissa Eliot; Ole Raaschou-Nielsen; Aslak Harbo Poulsen; James M Harrington; Chanelle J Howe; Katherine A James; Nina Roswall; Kim Overvad; Anne Tjønneland; Jaymie Meliker; Gregory A Wellenius Journal: Epidemiology Date: 2022-03-01 Impact factor: 4.822
Authors: Billy Amzal; Bettina Julin; Marie Vahter; Alicja Wolk; Gunnar Johanson; Agneta Akesson Journal: Environ Health Perspect Date: 2009-05-06 Impact factor: 9.031
Authors: Andy Menke; Paul Muntner; Ellen K Silbergeld; Elizabeth A Platz; Eliseo Guallar Journal: Environ Health Perspect Date: 2008-09-03 Impact factor: 9.031