Literature DB >> 16600851

Synaptic roles of Cdk5: implications in higher cognitive functions and neurodegenerative diseases.

Zelda H Cheung1, Amy K Y Fu, Nancy Y Ip.   

Abstract

Accumulating evidence indicates that cyclin dependent kinase 5 (Cdk5), through phosphorylating a plethora of pre- and postsynaptic proteins, functions as an essential modulator of synaptic transmission. Recent advances in the field of Cdk5 research have not only consolidated the in vivo importance of Cdk5 in neurotransmission but also suggest a pivotal role of Cdk5 in the regulation of higher cognitive functions and neurodegenerative diseases. In this review, we will discuss the recent findings on the emanating role of Cdk5 as a regulator of synaptic functions and plasticity.

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Year:  2006        PMID： 16600851     DOI： 10.1016/j.neuron.2006.02.024

Source DB:  PubMed          Journal:  Neuron        ISSN： 0896-6273            Impact factor:   17.173


  70 in total

1.  CDK5 interacts with Slo and affects its surface expression and kinetics through direct phosphorylation.

Authors:  Jun-Ping Bai; Alexei Surguchev; Powrnima Joshi; Liza Gross; Dhasakumar Navaratnam
Journal:  Am J Physiol Cell Physiol       Date:  2011-11-16       Impact factor: 4.249

Review 2.  Collapsin response mediator proteins regulate neuronal development and plasticity by switching their phosphorylation status.

Authors:  Naoya Yamashita; Yoshio Goshima
Journal:  Mol Neurobiol       Date:  2012-02-18       Impact factor: 5.590

3.  A quantitative analytic pipeline for evaluating neuronal activities by high-throughput synaptic vesicle imaging.

Authors:  Jing Fan; Xiaofeng Xia; Ying Li; Jennifer G Dy; Stephen T C Wong
Journal:  Neuroimage       Date:  2012-06-23       Impact factor: 6.556

4.  A 24-residue peptide (p5), derived from p35, the Cdk5 neuronal activator, specifically inhibits Cdk5-p25 hyperactivity and tau hyperphosphorylation.

Authors:  Ya-Li Zheng; Niranjana D Amin; Ya-Fang Hu; Parvathi Rudrabhatla; Varsha Shukla; Jyotshnabala Kanungo; Sashi Kesavapany; Philip Grant; Wayne Albers; Harish C Pant
Journal:  J Biol Chem       Date:  2010-08-18       Impact factor: 5.157

Review 5.  Sexual experience in female rodents: cellular mechanisms and functional consequences.

Authors:  Robert L Meisel; Amanda J Mullins
Journal:  Brain Res       Date:  2006-09-15       Impact factor: 3.252

6.  Reduced CXCL12/CXCR4 results in impaired learning and is downregulated in a mouse model of Alzheimer disease.

Authors:  A Parachikova; C W Cotman
Journal:  Neurobiol Dis       Date:  2007-07-10       Impact factor: 5.996

7.  Tissue-type plasminogen activator regulates p35-mediated Cdk5 activation in the postsynaptic terminal.

Authors:  Ariel Diaz; Valerie Jeanneret; Paola Merino; Patrick McCann; Manuel Yepes
Journal:  J Cell Sci       Date:  2019-02-28       Impact factor: 5.285

8.  CB1R regulates CDK5 signaling and epigenetically controls Rac1 expression contributing to neurobehavioral abnormalities in mice postnatally exposed to ethanol.

Authors:  Vikram Joshi; Shivakumar Subbanna; Madhu Shivakumar; Balapal S Basavarajappa
Journal:  Neuropsychopharmacology       Date:  2018-08-22       Impact factor: 7.853

9.  Cyclin-dependent kinase 5 phosphorylation of human septin SEPT5 (hCDCrel-1) modulates exocytosis.

Authors:  Niranjana D Amin; Ya-Li Zheng; Sashi Kesavapany; Jyotshnabala Kanungo; Tad Guszczynski; Ram K Sihag; Parvathi Rudrabhatla; Wayne Albers; Philip Grant; Harish C Pant
Journal:  J Neurosci       Date:  2008-04-02       Impact factor: 6.167

10.  PKCdelta regulates cortical radial migration by stabilizing the Cdk5 activator p35.

Authors:  Chun-tao Zhao; Kun Li; Jun-tao Li; Wang Zheng; Xu-jun Liang; An-qi Geng; Ning Li; Xiao-bing Yuan
Journal:  Proc Natl Acad Sci U S A       Date:  2009-11-24       Impact factor: 11.205
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