BACKGROUND: MSR1, PTEN, and KLF6 have been implicated as candidate susceptibility genes for prostate tumorigenesis. METHODS: Three hundred Jewish prostate cancer patients were screened for alterations in these genes. RESULTS: MSR1 was conserved in all patients. PTEN screening revealed a novel missense mutation and a silent change. Five KLF6 alterations were detected in 17 patients, including Q160X, the only nonsense KLF6 germline mutation described to date in a cancer patient. The KLF6 IVS1-27G>A polymorphism, recently associated with prostate cancer risk, was detected in 11.9% of the patients and 17.3% of the controls (P = 0.043). IVS1-27A allele frequency was significantly lower in prostate cancer patients (P = 0.030), specifically in Ashkenazi patients (P = 0.047) compared to controls. CONCLUSIONS: We found no evidence that MSR1 and PTEN germline mutations are associated with prostate cancer risk in Jews. The negative association between KLF6 IVS1-27A and prostate cancer risk supports a population-specific effect of susceptibility alleles in prostate tumorigenesis. Copyright 2005 Wiley-Liss, Inc.
BACKGROUND:MSR1, PTEN, and KLF6 have been implicated as candidate susceptibility genes for prostate tumorigenesis. METHODS: Three hundred Jewish prostate cancerpatients were screened for alterations in these genes. RESULTS:MSR1 was conserved in all patients. PTEN screening revealed a novel missense mutation and a silent change. Five KLF6 alterations were detected in 17 patients, including Q160X, the only nonsense KLF6 germline mutation described to date in a cancerpatient. The KLF6 IVS1-27G>A polymorphism, recently associated with prostate cancer risk, was detected in 11.9% of the patients and 17.3% of the controls (P = 0.043). IVS1-27A allele frequency was significantly lower in prostate cancerpatients (P = 0.030), specifically in Ashkenazi patients (P = 0.047) compared to controls. CONCLUSIONS: We found no evidence that MSR1 and PTEN germline mutations are associated with prostate cancer risk in Jews. The negative association between KLF6 IVS1-27A and prostate cancer risk supports a population-specific effect of susceptibility alleles in prostate tumorigenesis. Copyright 2005 Wiley-Liss, Inc.
Authors: Cilla Söderhäll; Izabella Baranowska Körberg; Hanh T T Thai; Jia Cao; Yougen Chen; Xufeng Zhang; Zu Shulu; Loes F M van der Zanden; Iris A L M van Rooij; Louise Frisén; Nel Roeleveld; Ellen Markljung; Ingrid Kockum; Agneta Nordenskjöld Journal: Eur J Hum Genet Date: 2014-07-02 Impact factor: 4.246
Authors: XiaoMei Liu; Alejandro Gomez-Pinillos; Charisse Loder; Enrique Carrillo-de Santa Pau; Ruifang Qiao; Pamela D Unger; Ralf Kurek; Carole Oddoux; Jonathan Melamed; Robert E Gallagher; John Mandeli; Anna C Ferrari Journal: Am J Pathol Date: 2012-07-20 Impact factor: 4.307